- 1. 14-3-3 Sigma
- [Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia. The protein is a putative cytoplasmic, p53-regulated homodimeric inhibitor of G2/M progression that is over expressed in squamous cell carcinoma of the head and neck. The gene is a member of a large 14-3-3 gene family. ( NCI )] (UMLS (NCI) C0972212) Epithelial Cell Marker Protein 1;
SFN;
Stratifin =Amino Acid, Peptide, or Protein; Enzyme; Indicator, Reagent, or Diagnostic Aid | - 29. Signal Transducer and Activator of Transcription 5B Gene
- [This gene is involved in signal transduction and activation of transcription. It plays a role in the immune response via stimulation of T-cell proliferation. ( NCI )] (UMLS (NCI) C1335876) STAT5B;
STAT5B Gene =Gene or Genome ;
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- 2. Sight
- [sense of sight. ( CSP )] (UMLS (NCI) C0042789) =Organism Function =sensation;
=eye accommodation;
eye movement;
visual fixation;
binocular vision;
visual field;
retinal adaptation;
interocular transfer;
brightness discrimination;
visual photosensitivity;
visual phototransduction;
| - 30. Signal Transducer and Activator of Transcription 6
- [This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this protein in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink) ( NCI )] (UMLS (NCI) C0297890) =Amino Acid, Peptide, or Protein; Biologically Active Substance
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- 3. sight for the blind
- [ ] (UMLS (CSP) C0599494) =Qualitative Concept
| - 31. Signal Transducer and Activator of Transcription 6, Interleukin-4 Induced Gene
- [This gene plays a role in signal transduction and activation of transcription. ( NCI )] (UMLS (NCI) C1335877) STAT6;
STAT6 Gene =Gene or Genome ;
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- 4. sigma receptor
- [A class of cell surface receptors recognized by its pharmacological profile. Sigma receptors were originally considered to be opioid receptors because they bind certain synthetic opioids. However they also interact with a variety of other psychoactive drugs, and their endogenous ligand is not known (although they can react to certain endogenous steroids). Sigma receptors are found in the immune, endocrine, and nervous systems, and in some peripheral tissues. ( MSH )] (UMLS (CSP) C0074504) =Amino Acid, Peptide, or Protein; Receptor ;
| - 32. Signal Transducer and Activator of Transcription Family Gene
- [Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI) ( NCI )] (UMLS (NCI) C1335960) STAT Family Gene =Gene or Genome ;
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- 5. Sigmoid
- [The portion of the colon that connects to the descending colon above and the rectum below. ( NCI )] (UMLS (HL7) C0227391) =Body Part, Organ, or Organ Component =Body Part;
| - 33. Signal Transduction Pathway
- [An elaboration of the known or inferred interactions involved in a signal transduction pathway. ( NCI )] (UMLS (NCI) C0086982) =Cell Function; Molecular Function ;
|
- 6. Sigmoid Artery
- (UMLS (NCI) C0226330) =Body Part, Organ, or Organ Component
| - 34. Signal-Induced Proliferation-Associated Gene 1 Gene
- [This gene plays a role in signal transduction and is putatively involved in cytoskeletal remodeling. ( NCI )] (UMLS (NCI) C1420070) SIPA1;
SIPA1 Gene =Gene or Genome |
- 7. Sigmoid Flexure
- (UMLS (NCI) C0682612) =Body Part, Organ, or Organ Component
| - 35. Signal-Regulatory Protein Beta 1
- [Expressed as 2 alternative isoforms in monocytes and dendritic cells by human SIRPB1 Gene (SIRPB Family/Ig Family), N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1 is a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling. Unlike SIRPAs, SIRPB1 lacks a C-terminal cytoplasmic SHP2-binding domain. SIRPB1 interacts with ITAM protein TYROBP/DAP12, resulting in SYK tyrosine kinase recruitment. (NCI) ( NCI )] (UMLS (NCI) C0907306) SIRP Beta 1;
SIRPB1 =Amino Acid, Peptide, or Protein; Receptor ;
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- 8. SIGMOIDECTOMY
- (UMLS (ICD9CM) C0192866) =Therapeutic or Preventive Procedure
| - 36. Signal-Regulatory Protein Beta 1 Gene
- [This gene plays a role in receptor signaling. ( NCI )] (UMLS (NCI) C1335826) SIRPB1;
SIRPB1 Gene;
=Gene or Genome ;
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- 9. sigmoidoscope
- [(sig-MOY-da-skope) A thin, lighted tube used to view the inside of the colon. ( NCI )] (UMLS (NCI) C0183294) =Medical Device ;
| - 37. Signaling Protein
- [Proteins or peptides that participate in signal transduction processes in the cell. ( NCI )] (UMLS (NCI) C1335962) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 10. Sigmoidoscopy
- (UMLS (HL7) C1548917) =Health Care Activity =Consent Type;
| - 38. Signatory_s Relationship to Subject
- (UMLS (HL7) C1547918) =Idea or Concept =HL7 Vocabulary Version 2.5;
=Self;
Parent;
Durable Power of Attorney in Healthcare Affairs;
Conservator;
Emergent Practitioner (practitioner judging case as emergency requiring care without a consent);
Non-Emergent Practitioner (i.e. medical ethics committee);
Next of Kin |
- 11. Sigmoidoscopy with Biopsy
- [Removal of tissue from the sigmoid colon for microscopic examination, using an endoscope. ( NCI )] (UMLS (NCI) C0192919) =Diagnostic Procedure
| - 39. Signature Code
- (UMLS (HL7) C1547907) =Intellectual Product =HL7 Vocabulary Version 2.5;
=Signed CMS-1500 claim form on file, e.g. authorization for release of any medical or other information necessary to process this claim and assignment of benefits.;
Signed authorization for assignment of benefits on file.;
Signature generated by provider because the patient was not physically present for services.;
Signed authorization for release of any medical or other information necessary to process this claim on file.;
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- 12. Sign
- (UMLS (HL7) C1547188) =Idea or Concept =Language Ability;
| - 40. Signature generated by provider because the patient was not physically present for services.
- (UMLS (HL7) C1549068) =Intellectual Product =Signature Code;
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- 13. Sign
- [Objective evidence of disease perceptible to the examining physician. ( NCI )] (UMLS (NCI) C0311392) =Sign or Symptom
| - 41. signed
- [Signature has been affixed, either written on file, or electronic (incl. digital) signature in Participation.signatureText. ( HL7V3.0 )] (UMLS (HL7) C1561610) =Idea or Concept =ParticipationSignature;
|
- 14. Sign and symptom
- (UMLS (HL7) C1546904) =Classification =Diagnosis Classification;
| - 42. Signed authorization for assignment of benefits on file.
- (UMLS (HL7) C1549067) =Intellectual Product =Signature Code;
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- 15. sign language
- [system of hand gestures used for communication by the deaf or by people speaking different languages. ( CSP )] (UMLS (CSP) C0037078) =Language ;
=language;
communication behavior;
deaf aid;
| - 43. Signed authorization for release of any medical or other information necessary to process this claim on file.
- (UMLS (HL7) C1549069) =Intellectual Product =Signature Code;
|
- 16. signal recognition particle
- [A cytosolic ribonucleoprotein complex that acts to induce elongation arrest of nascent presecretory and membrane proteins until the ribosome becomes associated with the rough endoplasmic reticulum. It consists of a 7S RNA and at least six polypeptide subunits (relative molecular masses 9, 14, 19, 54, 68, and 72K). ( MSH )] (UMLS (CSP) C0074512) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 44. Signed CMS-1500 claim form on file, e.g. authorization for release of any medical or other information necessary to process this claim and assignment of benefits.
- (UMLS (HL7) C1549066) =Intellectual Product =Signature Code;
|
- 17. Signal Recognition Particle 19kDa
- [Expressed by human SRP19 Gene (SRP19 Family), 144-aa cytoplasmic Signal Recognition Particle 19kDa, with 7 C-terminal Lys interrupted by 2 Gly residues, is involved in signal-recognition-particle assembly (SRP). Monomeric SRP19 mediates binding of the monomeric 54-kDa subunit and binds directly to the SRP 7SLRNA helix 6 stem-loop structure. Mediating signal recognition, translational arrest, and ER targeting by docking protein interaction, the SRP complex consists of a 7SLRNA and SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 protein subunits. SRP9/SRP14 (Alu domain) and SRP68/SRP72 (S domain) bind to 7SLRNA as heterodimers. (NCI) ( NCI )] (UMLS (NCI) C1335958) SRP19 =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 45. Signed statement on file
- (UMLS (HL7) C1549470) =Idea or Concept =Eligibility Source;
|
- 18. Signal Recognition Particle 19kDa Gene
- [This gene plays a role in the mediation of RNA-protein interactions. ( NCI )] (UMLS (NCI) C1335862) SRP19;
SRP19 Gene =Gene or Genome ;
| - 46. Signet Ring Cell
- [An epithelial neoplastic cell containing cytoplasmic mucin. The presence of mucin pushes the nucleus of the cell to the periphery, assuming a configuration resembling a signet ring. ( NCI )] (UMLS (NCI) C0333727) =Cell ;
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- 19. Signal Transducer and Activator of Transcription
- [STAT proteins have the dual function of signal transduction and activation of transcription. These proteins are activated by phosphorylation on tyrosine in response to different ligands after which they form homodimers or heterodimers that translocate to the cell nucleus where they either directly bind to DNA or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (from OMIM 600555) ( NCI )] (UMLS (NCI) C1366753) STAT;
STAT Protein =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 47. Significance
- [In statistics, a number that expresses the probability that the result of a given experiment or study could have occurred purely by chance. This number can be a margin of error or it can indicate a confidence level. ( NCI )] (UMLS (NCI) C0237881) =Quantitative Concept
|
- 20. Signal Transducer and Activator of Transcription 1, 91kDa Gene
- [This gene plays a role in signal transduction and activation of transcription. It is involved in cell organization/biogenesis. ( NCI )] (UMLS (NCI) C1335872) STAT1;
STAT1 Gene =Gene or Genome ;
| - 48. Significance Level
- [The probability of a type I error of a statistical hypothesis test, a fixed probability of wrongly rejecting the null hypothesis H0, if it is in fact true. It is set by the investigator in relation to the consequences of such an error. The often chosen significance level is 5%. ( NCI )] (UMLS (NCI) C0814896) =Research Activity
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- 21. Signal Transducer and Activator of Transcription 2
- [This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. (LocusLink) ( NCI )] (UMLS (NCI) C0295166) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 49. Significant
- (UMLS (HL7) C1546944) =Qualitative Concept =Event Seriousness;
|
- 22. Signal Transducer and Activator of Transcription 2, 113kDa Gene
- [This gene is involved in signal transduction and activation of transcription. ( NCI )] (UMLS (NCI) C1335873) STAT2;
STAT2 Gene =Gene or Genome ;
| - 50. Significant
- [A term applied to differences, correlations, cause-and-effect relationships, etc., to indicate that they are noticeable, probably too closely correlated to be attributed to chance and therefore indicating a systematic relation: substantial, fairly large; also having consequence or import, important in effect or meaning. In statistics significant ordinarily indicates a probability of not less than 95 percent, while highly significant indicates a probability of not less than 99 percent. ( NCI )] (UMLS (NCI) C0750502) =Idea or Concept
|
- 23. Signal Transducer and Activator of Transcription 3 (Acute-Phase Response Factor) Gene
- [This gene plays a role in signal transduction and activation of transcription. It is involved in regulation of both apoptosis and cell growth. ( NCI )] (UMLS (NCI) C1367307) STAT3;
STAT3 Gene =Gene or Genome | - 51. Significant change down
- (UMLS (HL7) C1548136) =Qualitative Concept =Abnormal flags;
|
- 24. Signal Transducer and Activator of Transcription 4
- [This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. (LocusLink) ( NCI )] (UMLS (NCI) C0255034) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 52. Significant change up
- (UMLS (HL7) C1548143) =Qualitative Concept =Abnormal flags;
|
- 25. Signal Transducer and Activator of Transcription 4 Gene
- [This gene is involved in signal transduction and activation of transcription. It plays a role in regulation of T-helper cell differentiation. ( NCI )] (UMLS (NCI) C1335874) STAT4;
STAT4 Gene =Gene or Genome ;
| - 53. significant other
- [A person who is important to one's well being; especially a spouse or one in a similar relationship. (The player is the one who is important) ( HL7V3.0 )] (UMLS (HL7) C1553704) =Intellectual Product =Family Member;
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- 26. Signal Transducer and Activator of Transcription 5A
- [This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart is found to induce the expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function in cells. (from LocusLink) ( NCI )] (UMLS (NCI) C1366394) STAT1;
STAT5A =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 54. signing authority or officer
- [The role of a person (player) who is the officer or signature authority for of a scoping entity, usually an organization (scoper). ( HL7V3.0 )] (UMLS (HL7) C1551365) =Idea or Concept =assigned entity;
|
- 27. Signal Transducer and Activator of Transcription 5A Gene
- [This gene plays a role in signal transduction and activation of transcription. It is involved in the immune response via stimulation of T-cell proliferation. ( NCI )] (UMLS (NCI) C1335875) STAT5A;
STAT5A Gene =Gene or Genome ;
| - 55. Signs and symptoms in breast
- [ ] (UMLS (ICD9CM) C0156323) =Sign or Symptom ;
|
- 28. Signal Transducer and Activator of Transcription 5B
- [This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. (LocusLink) ( NCI )] (UMLS (NCI) C1335959) STAT5B =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 56. Sigosix
- (UMLS (NCI) C0878479) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
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