- 101. CD8 Cell
- [A subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes and suppressor T-lymphocytes. (MeSH) ( NCI )] (UMLS (NCI) C0242629) =Cell ;
| - 151. CDDP/5-FU/L-CF
- (UMLS (NCI) C0338233) =Therapeutic or Preventive Procedure
|
- 102. CD8 molecule
- [suppressor T-lymphocyte marker that functions as a receptor for MHC class I antigen. ( CSP )] (UMLS (CSP) C0085358) =Amino Acid, Peptide, or Protein; Immunologic Factor =CD antigen;
| - 152. CDDP/5-FU/MITO/VCR
- (UMLS (NCI) C0279795) =Therapeutic or Preventive Procedure
|
- 103. CD80
- [This gene is involved in the stimulation of T-cells and in immune responses. ( NCI )] (UMLS (NCI) C1366561) CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) Gene;
CD80 Gene =Gene or Genome | - 153. CDDP/5-FU/MTX
- (UMLS (NCI) C0055981) =Therapeutic or Preventive Procedure
|
- 104. CD80 Breast Cancer Vaccine
- [A vaccine comprised of CD80-transfected allogenic breast cancer cells to induce T-cell response. ( NCI )] (UMLS (NCI) C0677969) =Pharmacologic Substance; Immunologic Factor ;
| - 154. CDDP/5-FU/ONYX-015
- (UMLS (NCI) C0678041) =Therapeutic or Preventive Procedure ;
|
- 105. CD82
- [This gene plays a role in the regulation of membrane receptor functions. ( NCI )] (UMLS (NCI) C0812444) CD82 Antigen Gene;
CD82 Gene =Gene or Genome ;
| - 155. CDDP/5-FU/SR-4233
- (UMLS (NCI) C0338326) =Therapeutic or Preventive Procedure ;
|
- 106. CD87
- [High affinity cellular receptor for urokinase plasminogen activator (uPA). Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs. Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion. ( NCI )] (UMLS (NCI) C0071216) =Amino Acid, Peptide, or Protein; Receptor ;
| - 156. CDDP/5-FU/TAX
- (UMLS (NCI) C0281340) =Therapeutic or Preventive Procedure
|
- 107. CD94
- [Preferentially expressed in NK lymphocytes, CD94 Antigen (179-amino acid, 20.5-kD CD94-A and 148-amino acid CD94 ALT) is encoded by KLRD1 Gene (C-Lectin Family) and may regulate NK cell function. A type II membrane protein (external C-terminus), CD94 contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0382839) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
| - 157. CDDP/5-FU/TXT
- (UMLS (NCI) C0678019) =Therapeutic or Preventive Procedure
|
- 108. CD97
- [CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0300533) =Amino Acid, Peptide, or Protein; Immunologic Factor
| - 158. CDDP/5-FU/VBL
- (UMLS (NCI) C0279978) =Therapeutic or Preventive Procedure
|
- 109. CD97
- [This gene plays a role in cellular adhesion and signal transduction. ( NCI )] (UMLS (NCI) C1332718) CD97 Antigen Gene;
CD97 Gene;
=Gene or Genome ;
| - 159. CDDP/5-FU/VCR
- (UMLS (NCI) C0279123) =Therapeutic or Preventive Procedure
|
- 110. CDA Level 1 Multipart
- [The HL7 clinical document Architecture, Level 1 MIME package. ( HL7V3.0 )] (UMLS (HL7) C1555003) =Intellectual Product =MultipartMediaType;
| - 160. CDDP/5-FU/VP-16
- (UMLS (NCI) C0115560) =Therapeutic or Preventive Procedure
|
- 111. CDA Level One clinical document
- [A clinical document that conforms to Level One of the HL7 Clinical Document Architecture (CDA) ( HL7V3.0 )] (UMLS (HL7) C1554975) =Intellectual Product =clinical document;
| - 161. CDDP/CF/5-FU
- (UMLS (NCI) C0070493) =Therapeutic or Preventive Procedure
|
- 112. CDC
- [An agency of the US Public Health Service that serves as the national focus for developing and applying disease prevention and control, environmental health and health promotion and health education activities designed to improve the health of the people of the United States. The CDC is responsible for controlling the induction and spread of infectious diseases, and provides consultation and assistance to other nations and international agencies to assist in improving their disease prevention and control, environmental health, and health promotion activities. ( NCI )] (UMLS (NCI) C0007670) =Health Care Related Organization
| - 162. CDDP/CF/5-FU/HU
- (UMLS (NCI) C0280926) =Therapeutic or Preventive Procedure
|
- 113. CDC Analyte Codes
- [Public Health Practice Program Office, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30421. Also available via FTP: ftp.cdc.gov/pub/laboratory _info/CLIA and Gopher: gopher.cdc.gov:70/11/laboratory_info/CLIA ( HL7V3.0 )] (UMLS (HL7) C1550189) =Intellectual Product =Code;
CodeSystem | - 163. CDDP/CF/5-FU/IFN-A
- (UMLS (NCI) C0338140) =Therapeutic or Preventive Procedure
|
- 114. CDC Methods/Instruments Codes
- [Public Health Practice Program Office, Centers for Disease Control and Prevention, 4770 Buford Highway, Atlanta, GA, 30421. Also available via FTP: ftp.cdc.gov/pub/laboratory _info/CLIA and Gopher: gopher.cdc.gov:70/11/laboratory_info/CLIA ( HL7V3.0 )] (UMLS (HL7) C1550190) =Intellectual Product =Code;
CodeSystem | - 164. CDDP/CF/5-FU/MITO
- (UMLS (NCI) C0280709) =Therapeutic or Preventive Procedure
|
- 115. CDC Surveillance
- [CDC Surveillance Codes. For data unique to specific public health surveillance requirements. Epidemiology Program Office, Centers for Disease Control and Prevention, 1600 Clifton Rd, Atlanta, GA, 30333. (404) 639-3661. ( HL7V3.0 )] (UMLS (HL7) C1550191) =Intellectual Product =Code;
CodeSystem | - 165. CDDP/CF/5-FU/TXT
- (UMLS (NCI) C0281669) =Therapeutic or Preventive Procedure
|
- 116. CDC Vaccine Codes
- [National Immunization Program, Centers for Disease Control and Prevention, 1660 Clifton Road, Atlanta, GA, 30333 ( HL7V3.0 )] (UMLS (HL7) C1550194) =Intellectual Product =Code;
CodeSystem | - 166. CDDP/CF/5-FU/VP-16
- (UMLS (NCI) C0281429) =Therapeutic or Preventive Procedure
|
- 117. CDC Vaccine Manufacturer Codes
- [National Immunization Program, Centers for Disease Control and Prevention, 1660 Clifton Road, Atlanta, GA, 30333 ( HL7V3.0 )] (UMLS (HL7) C1547158) =Intellectual Product =Code;
CodeSystem | - 167. CDDP/CF/CTX/MTX/VCR/VP-16
- (UMLS (NCI) C0678065) =Therapeutic or Preventive Procedure ;
|
- 118. CDC18 (Cell Division Cycle 18, S. pombe, Homolog)-Like
- [CDC6 Cell Division Cycle 6 Homolog, encoded by the CDC6 gene, is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0534434) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 168. CDDP/CF/DM/DOX/FUDR
- (UMLS (NCI) C0281531) =Therapeutic or Preventive Procedure
|
- 119. CDC2
- [A serine/threonine protein kinase subunit of the M-phase promoting factor complex, required for entry into S-phase and mitosis. A member of the CDC2/CDKX subfamily, p34(cdc2) forms a complex with a Cyclin, and phosphorylates RNA Polymerase II. CDC2 gene expression is transcriptionally regulated and phosphorylation regulates cdc2 activity. (from SWISS-PROT P06493, OMIM 116940, and NCI) ( NCI )] (UMLS (NCI) C0080054) =Amino Acid, Peptide, or Protein; Enzyme
| - 169. CDDP/CF/DOX/5-FU
- (UMLS (NCI) C0279429) =Therapeutic or Preventive Procedure
|
- 120. CDC2
- [This gene is involved in the cellular transition from the G1/S phase and from the G2/M phase of the cell cycle. ( NCI )] (UMLS (NCI) C1332721) CDC2 Gene;
Cell Division Cycle 2, G1 to S and G2 to M Gene;
=Gene or Genome ;
| - 170. CDDP/CF/DOX/FUDR
- (UMLS (NCI) C0281530) =Therapeutic or Preventive Procedure
|
- 121. CDC2-Related Kinase
- [Cyclin-Dependent Kinase-Like 2, encoded by the CDKL2 gene, is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0534157) =Amino Acid, Peptide, or Protein; Enzyme
| - 171. CDDP/CF/FUDR
- (UMLS (NCI) C0281355) =Therapeutic or Preventive Procedure
|
- 122. CDC2-Related Protein Kinase
- [Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0108855) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 172. CDDP/CPFX/CTX/PTX/VP-16
- (UMLS (NCI) C0281434) =Therapeutic or Preventive Procedure
|
- 123. CDC21
- [Encoded by human MCM4 Gene (MCM Family), 863-aa 97-kDa DNA Replication Licensing Factor MCM4 is a highly conserved protein that binds to origin recognition complexes, is essential for replication initiation, and prevents over-replication. A stable complex of MCM4, MCM6, and MCM7 associates with MCM2 specifically bound to histone H3. A key component of the pre-replication complex, hexameric MCM2-7 complex is likely involved in formation of replication forks and recruitment of replication factors. MCM2/4/6/7 complex possesses ATP-dependent DNA helicase activity and may initiate replication as a DNA unwinding enzyme. MCM4 phosphorylation by Cyclin/CDK1,2 suppresses helicase activity and chromatin binding, regulating replication. MCM4 is highly phosphorylated in mitotic cells. (NCI) ( NCI )] (UMLS (NCI) C0663296) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 173. CDDP/CPFX/G-CSF/VP-16
- (UMLS (NCI) C0281554) =Therapeutic or Preventive Procedure
|
- 124. CDC25
- [The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested, that the Ras-GEF activity of this protein in brain, can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. ( NCI )] (UMLS (NCI) C0379310) =Amino Acid, Peptide, or Protein; Biologically Active Substance
| - 174. CDDP/CPFX/VP-16
- (UMLS (NCI) C0281553) =Therapeutic or Preventive Procedure
|
- 125. cdc25 gene product
- [ ] (UMLS (CSP) C0167138) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 175. CDDP/CPT-11
- (UMLS (NCI) C0281724) =Therapeutic or Preventive Procedure
|
- 126. CDC25A
- [Cell Division Cycle 25A Protein (CDC25A), encodes by the CDC25A gene, is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. The CDC25A gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary) ( NCI )] (UMLS (NCI) C0538918) =Amino Acid, Peptide, or Protein; Enzyme
| - 176. CDDP/CPT-11/TAX
- (UMLS (NCI) C0796484) Cisplatin/Irinotecan/Paclitaxel =Therapeutic or Preventive Procedure
|
- 127. CDC25A
- [This oncogene is involved in cell cycle control. ( NCI )] (UMLS (NCI) C1332719) CDC25A Gene;
Cell Division Cycle 25A Gene;
=Gene or Genome ;
| - 177. CDDP/CTX/5-FU/MTX/PRED
- (UMLS (NCI) C0280874) =Therapeutic or Preventive Procedure ;
|
- 128. CDC28
- [A protein kinase encoded by the Saccharomyces cerevisiae CDC28 gene and required for progression from the G1 PHASE to the S PHASE in the CELL CYCLE. ( MSH )] (UMLS (CSP) C0007511) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 178. CDDP/CTX/5-FU/VCR
- (UMLS (NCI) C0279407) =Therapeutic or Preventive Procedure
|
- 129. CDC2L1
- [Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI) ( NCI )] (UMLS (NCI) C0138869) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 179. CDDP/CTX/CYSP/TAX
- (UMLS (NCI) C0392958) =Therapeutic or Preventive Procedure
|
- 130. CDC2L1
- [This gene is involved in cell cycle control. ( NCI )] (UMLS (NCI) C1332720) CDC2L1 Gene;
Cell Division Cycle 2-Like 1 (PITSLRE Proteins) Gene;
=Gene or Genome ;
| - 180. CDDP/CTX/DAVA
- (UMLS (NCI) C0246101) =Therapeutic or Preventive Procedure
|
- 131. CDC37
- [This gene regulates the progression of cells through the G1 phase of the cell cycle. ( NCI )] (UMLS (NCI) C1332722) CDC37 Cell Division Cycle 37 Homolog (S. cerevisiae) Gene;
CDC37 Gene;
=Gene or Genome ;
| - 181. CDDP/CTX/DAVA/DOX
- (UMLS (NCI) C0280022) =Therapeutic or Preventive Procedure
|
- 132. CDC42
- [Cell Division Cycle 42, encoded by the CDC42 gene, is a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant transformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI) ( NCI )] (UMLS (NCI) C0082645) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 182. CDDP/CTX/DAVA/DOX/MTX/VCR/VP-16
- (UMLS (NCI) C0279909) =Therapeutic or Preventive Procedure
|
- 133. CDC42
- [This gene is involved in the regulation of the actin cytoskeleton. ( NCI )] (UMLS (NCI) C1366537) CDC42 Gene;
Cell Division Cycle 42 Gene =Gene or Genome | - 183. CDDP/CTX/dFdC/DM/VP-16
- (UMLS (NCI) C0796323) Cisplatin/Cyclophosphamide/Dexamethasone/Etoposide/Gemcitabine;
=Therapeutic or Preventive Procedure |
- 134. CDC45
- [CDC45-Related Protein, encoded by the CDC45L gene, was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. CDC45-Related Protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggest that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. (from LocusLink) ( NCI )] (UMLS (NCI) C0755538) CDC45 (Cell Division Cycle 45, S. cerevisiae, Homolog)-Like;
CDC45 Cell Division Cycle 45-Like (S. cerevisiae);
CDC45L;
CDC45L2;
CDC45-Like;
CDC45-Related Protein;
Cell Division Cycle 45, S. cerevisiae, Homolog-Like;
Cell Division Cycle 45-Like 2;
PORC-PI-1 =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 184. CDDP/CTX/DHAD
- (UMLS (NCI) C0281690) =Therapeutic or Preventive Procedure
|
- 135. CDC45 Cell Division Cycle 45-Like (S. Cerevisiae) Gene
- [This gene plays a role in the initiation of DNA replication. ( NCI )] (UMLS (NCI) C1332724) CDC45L;
CDC45L Gene;
=Gene or Genome ;
| - 185. CDDP/CTX/DM/VP-16
- (UMLS (NCI) C0796328) Cisplatin/Cyclophosphamide/Dexamethasone/Etoposide;
=Therapeutic or Preventive Procedure |
- 136. CDC46
- [Encoded by E2F growth-regulated human MCM5 Gene (MCM Family), 734-aa 82-kDa nuclear DNA Replication Licensing Factor MCM5 is a chromatin-binding protein that binds to origin recognition complexes, is required for replication initiation, is structurally similar to replication initiation protein CDC46 (S. cerevisiae), and is related to ATP-dependent helicases. Upregulated in the G0 to G1/S transition, MCM5 may participate in cell cycle regulation. A stable dimeric complex of MCM5/MCM3 associates with replication-specific DNA polymerase alpha-primase complex. MCM3 is acetylated by MCM3AP. MCM proteins also associate with RNA Pol II holoenzyme as components of the transcriptional apparatus. MCM5 interacts directly with the TAD of STAT1, enhancing transcription activation. (NCI) ( NCI )] (UMLS (NCI) C0296863) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
| - 186. CDDP/CTX/DOX/5-FU
- (UMLS (NCI) C0054607) =Therapeutic or Preventive Procedure ;
|
- 137. CDC47
- [Encoded by human MCM7 Gene (MCM Family), 719-aa 81-kDa DNA Replication Licensing Factor MCM7 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complexes and prevents over-replication. A stable MCM2/4/6/7 complex possesses DNA helicase activity and may act as a DNA unwinding enzyme. CDC45 binds to MCM7 and DNA polymerase alpha p70 subunit in the final sequential step of active initiation complex assembly and recruits DNA polymerase alpha to origins of replication. Nonenzymatic p70 forms a tight complex with the catalytic DNA polymerase alpha p180 subunit. The hexameric MCM2-7 complex is a key component of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. CDK4 associates with MCM7 and MCM7 binds RB1/RB. (NCI) ( NCI )] (UMLS (NCI) C1333241) CDC47 Homolog;
DNA Replication Licensing Factor MCM7;
Minichromosome Maintenance Protein 7;
P1.1-MCM3;
P1CDC47;
p85MCM;
PNAS-146 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 187. CDDP/CTX/DOX/5-FU/MTX/VCR/VP-16
- (UMLS (NCI) C0279843) =Therapeutic or Preventive Procedure
|
- 138. CDC6
- [This gene plays a role in regulation of the early steps of DNA replication. ( NCI )] (UMLS (NCI) C1332725) CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae) Gene;
CDC6 Gene;
=Gene or Genome ;
| - 188. CDDP/CTX/DOX/5-FU/VCR/VP-16
- (UMLS (NCI) C0281159) =Therapeutic or Preventive Procedure ;
|
- 139. CDC7
- [CDC7 Cell Division Cycle 7, encoded by the CDC7 gene, is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of this protein appear constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. This protein is essential for initiation of DNA replication and plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0108836) =Amino Acid, Peptide, or Protein; Enzyme ;
| - 189. CDDP/CTX/DOX/DTIC/NM/VCR
- (UMLS (NCI) C0126735) =Therapeutic or Preventive Procedure ;
|
- 140. CDC7
- [This gene is involved in the initiation of DNA replication and inhibition of cell proliferation. It also plays a putative role in the mediation of cell cycle progression. ( NCI )] (UMLS (NCI) C1332727) CDC7 Cell Division Cycle 7 (S. Cerevisiae) Gene;
CDC7 Gene;
=Gene or Genome ;
| - 190. CDDP/CTX/DOX/DTIC/VCR/VP-16
- (UMLS (NCI) C0279125) =Therapeutic or Preventive Procedure
|
- 141. CDC7L1 Kinase Complex
- [The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1. ( NCI )] (UMLS (NCI) C1332726) =Amino Acid, Peptide, or Protein; Enzyme
| - 191. CDDP/CTX/DOX/FT
- (UMLS (NCI) C0059997) =Therapeutic or Preventive Procedure ;
|
- 142. CDC91 Cell Division Cycle 91-Like 1 (S. Cerevisiae) Gene
- [This gene is involved in the regulation of cell division. ( NCI )] (UMLS (NCI) C1423732) CDC91L1;
CDC91L1 Gene =Gene or Genome | - 192. CDDP/CTX/DOX/G-CSF/VP-16
- (UMLS (NCI) C0338155) =Therapeutic or Preventive Procedure
|
- 143. CDC91L1
- [Ubiquitously expressed by human CDC91L1 Gene (PIGU Family), conserved 435-aa 50-kD GPI Transamidase Component PIGU is an integral ER membrane protein containing 9 putative transmembrane domains, with similarity to Cdc91 (S. cerevisiae), and a critical subunit of the GPI transamidase complex (PIGU, PIGK/GPI8, PIGS, PIGT, and GPAA1/GAA1) that attaches posttranslational GPI-anchors to the C-termini of cell surface proteins attached to membranes via GPI. PIGU may be involved in recognition of the GPI attachment signal or the lipid portion of GPI. (NCI) ( NCI )] (UMLS (NCI) C1453971) CDC91-Like 1 Protein;
Cell Division Cycle 91-Like 1 Protein;
Cell Division Cycle Protein 91-Like 1 Protein;
GPI Transamidase Component;
GPI Transamidase Component PIGU;
Phosphatidylinositol-Glycan Biosynthesis Class U Protein;
PIGU;
UNQ3055/PRO9875 =Amino Acid, Peptide, or Protein; Biologically Active Substance | - 193. CDDP/CTX/DOX/GM-CSF/VP-16
- (UMLS (NCI) C0279304) =Therapeutic or Preventive Procedure
|
- 144. CDDP/13-CRA
- (UMLS (NCI) C0338347) =Therapeutic or Preventive Procedure ;
| - 194. CDDP/CTX/DOX/MNI
- (UMLS (NCI) C0279772) =Therapeutic or Preventive Procedure
|
- 145. CDDP/5-FU
- (UMLS (NCI) C0280055) =Therapeutic or Preventive Procedure
| - 195. CDDP/CTX/DOX/MTX/VCR/VP-16
- (UMLS (NCI) C0280675) =Therapeutic or Preventive Procedure
|
- 146. CDDP/5-FU/G-CSF/HU
- (UMLS (NCI) C0280965) =Therapeutic or Preventive Procedure ;
| - 196. CDDP/CTX/DOX/PRED
- (UMLS (NCI) C0280837) =Therapeutic or Preventive Procedure
|
- 147. CDDP/5-FU/HU
- (UMLS (NCI) C0280964) =Therapeutic or Preventive Procedure ;
| - 197. CDDP/CTX/DOX/TZT
- (UMLS (NCI) C0279271) =Therapeutic or Preventive Procedure
|
- 148. CDDP/5-FU/IFN-A
- (UMLS (NCI) C0338146) =Therapeutic or Preventive Procedure
| - 198. CDDP/CTX/DOX/VCR/VP-16
- (UMLS (NCI) C0111342) =Therapeutic or Preventive Procedure
|
- 149. CDDP/5-FU/IFN-A/VP-16
- (UMLS (NCI) C0338162) =Therapeutic or Preventive Procedure
| - 199. CDDP/CTX/DOX/VP-16
- (UMLS (NCI) C0520526) =Therapeutic or Preventive Procedure ;
|
- 150. CDDP/5-FU/IL-2
- (UMLS (NCI) C0280492) =Therapeutic or Preventive Procedure ;
| - 200. CDDP/CTX/DTC
- (UMLS (NCI) C0279122) =Therapeutic or Preventive Procedure
|
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