- 101. 4-Chloroamphetamine
- [Chlorinated analog of AMPHETAMINE. Potent neurotoxin that causes release and eventually depletion of serotonin in the CNS. It is used as a research tool. ( MSH )] (UMLS (NCI) C0030131) =Organic Chemical; Pharmacologic Substance ;
| - 151. C & S-SPLEEN/MARROW
- [ ] (UMLS (ICD9CM) C0177887) =Laboratory Procedure
|
- 102. 4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol
- [A phenothiazine derivative and a dopamine antagonist with antiemetic and antipsychotic properties. Perphenazine blocks postsynaptic dopamine 2(D2) receptors in the mesolimbic and medullary chemoreceptor trigger zone (CTZ), thereby preventing the excess of dopamine in the brain. This leads to reduction in psychotic symptoms, such as hallucinations and delusions. Perphenazine appears to exert its antiemetic activity by blocking the dopamine and histamine-1 receptor in the CTZ thereby relieving nausea and vomiting in the brain. In addition, perphenazine binds to alpha-adrenergic receptors. ( NCI )] (UMLS (NCI) C0031184) =Organic Chemical; Pharmacologic Substance =Phenothiazine;
[CN701] PHENOTHIAZINES/RELATED, ANTIPSYCHOTICS =PERPHENAZINE 16 MG;
PERPHENAZINE 2 MG;
PERPHENAZINE 16 MG/5ML;
PERPHENAZINE 8 MG;
PERPHENAZINE 4 MG | - 152. C & S-UPPER GI
- [ ] (UMLS (ICD9CM) C0177903) =Laboratory Procedure
|
- 103. 4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone
- [USP lists as an antipsychotic and as an "antidyskinetic" used in Tourette syndrome. ( CSP )] (UMLS (NCI) C0018546) =Organic Chemical; Pharmacologic Substance =butyrophenone;
piperidine;
[CN700] ANTIPSYCHOTICS;
Dopamine Antagonist;
[CN709] ANTIPSYCHOTICS, OTHER;
=HALOPERIDOL DECANOATE;
HALOPERIDOL LACTATE;
HALOPERIDOL DECANOATE;
HALOPERIDOL LACTATE;
HALOPERIDOL 0.5 MG;
HALOPERIDOL 1 MG;
HALOPERIDOL 10 MG;
HALOPERIDOL 2 MG;
HALOPERIDOL 2 MG/ML;
HALOPERIDOL 20 MG;
HALOPERIDOL 5 MG;
HALOPERIDOL 5 MG/ML;
| - 153. C & S-UPPER URINARY
- [ ] (UMLS (ICD9CM) C0177935) =Laboratory Procedure
|
- 104. 5-Chloro-2,4-pyridinediol
- [A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines. ( NCI )] (UMLS (NCI) C0535459) =Organic Chemical; Pharmacologic Substance
| - 154. c abl
- [ ] (UMLS (CSP) C0079050) =Gene or Genome
|
- 105. 5-Chloro-2-(6-methylpyridin-3-yl)-3-(4-methylsulfonylphenyl) Pyridine
- [A synthetic, nonsteroidal anti-inflammatory drug (NSAID) with antipyretic, analgesic ,and potential antineoplastic properties. Etoricoxib specifically binds to and inhibits the enzyme cyclooxygenase-2 (COX-2), resulting in inhibition of the conversion of arachidonic acid into prostaglandins. Inhibition of COX-2 may induce apoptosis and inhibit tumor cell proliferation and angiogenesis. ( NCI )] (UMLS (NCI) C0972314) Etoricoxib;
ETORICOXIB UNIDENTIFIED;
=Organic Chemical; Pharmacologic Substance ;
| - 155. C cadherin
- [ ] (UMLS (CSP) C0598040) =Amino Acid, Peptide, or Protein; Biologically Active Substance
|
- 106. 51 chromium release assay
- [effector Cytotoxic T Lymphocytes (CTL) bind targets (infected cells) bearing virus peptide on syngeneic Class I MHC and signal the targets to undergo apoptosis; if the targets are labeled with 51Chromium before the CTL are added, the amount of 51Cr released into the supernatant is proportional to the number of targets killed. ( CSP )] (UMLS (CSP) C0201618) =Laboratory Procedure =immunologic assay;
| - 156. C Cell Adenocarcinoma with Amyloid Stroma
- [A medullary thyroid gland carcinoma characterized by the presence of amyloid stroma. The majority of medullary carcinomas of the thyroid gland are associated with amyloid deposits. The latter are highlighted with Congo red staining method. ( NCI )] (UMLS (NCI) C0334379) =Neoplastic Process
|
- 107. 520C9x22 Bispecific Antibody
- [A partially humanized bivalent antibody targeting cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) against HER2/neu-overexpressing tumor cells. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody, 520C9, and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody, H22. While HER2/neu is overexpressed in a variety of malignancies, expression of Fc gammaRI is limited primarily to cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells. Therefore, HER2/neu expressing tumor cells bound by MDX-H210 can be selectively recognized by effector cells and triggers antibody-dependent cell-mediated cytotoxicity (ADCC), resulting in tumor cell lysis. ( NCI )] (UMLS (NCI) C0281736) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Immunologic Factor
| - 157. C Cell Carcinoma
- [two types are found, familial and sporadic; if familial, the carcinoma is bilateral and may be associated with other benign or malignant endocrine organ tumors; if sporadic, it is unilateral; thyroidectomy and radiation therapy are treatments of choice. ( CSP )] (UMLS (NCI) C0238462) =Neoplastic Process =Neoplasm of the Thyroid;
|
- 108. 566C80
- (UMLS (NCI) C0700939) =Organic Chemical; Pharmacologic Substance ;
| - 158. C Chemokine
- [Gamma chemokines are cytokines that lack adjacent cysteine residues and act as chemoattractants for lymphocytes. Most members of the chemokind family have at least four conserved cysteine residues that form two intramolecular disulfide bonds. ( NCI )] (UMLS (NCI) C0524932) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
|
- 109. 6-Chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate(salt)
- [The mesylate salt form of fenoldopam, a benzazepine derivative with rapid-acting vasodilator activity. Fenoldopam mesylate is a racemic mixture of S- and R- isomers; the latter is responsible for the biological activity and has a significantly higher affinity for dopamine D1-like receptors (D1 and D5) as well as moderate affinity to alpha2-adrenoceptors. This agent selectively activates the dopamine D1-like receptor, thereby causing vasodilatation and increasing renal perfusion. ( NCI )] (UMLS (NCI) C0700481) =Organic Chemical; Pharmacologic Substance =FENOLDOPAM;
=FENOLDOPAM MESYLATE 10 MG/ML;
| - 159. C elegans
- [roundworm important research model in animal biology, especially for the genetic and molecular basis of development and behavior. ( CSP )] (UMLS (CSP) C0162610) =Invertebrate ;
=Nematoda;
|
- 110. 6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
- [The hydrogenated derivative of chlorothiazide, a thiazide diuretic with antihypertensive and anti-urolithic effects. This agent binds to the electroneutral Na-K-Cl cotransporter (NKCC) and thereby impairs Na+, K+ and Cl- reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in urinary excretion of sodium, chloride, potassium, bicarbonate and water subsequently reducing plasma and extracellular fluid volume leading to a reduction in blood pressure. Hydrochlorothiazide also decreases urinary calcium and uric acid excretion by direct action on the distal tubule. ( NCI )] (UMLS (NCI) C0020261) =Organic Chemical; Pharmacologic Substance ;
=chlorothiazide;
[CV701] THIAZIDES/RELATED DIURETICS =2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-Dioxide;
Hydrochlorothiazide 10 MG/ML;
HYDROCHLOROTHIAZIDE 100 MG;
HYDROCHLOROTHIAZIDE 12.5 MG;
HYDROCHLOROTHIAZIDE 15 MG;
HYDROCHLOROTHIAZIDE 25 MG;
HYDROCHLOROTHIAZIDE 30 MG;
HYDROCHLOROTHIAZIDE 50 MG;
HYDROCHLOROTHIAZIDE 6.25 MG;
HYDROCHLOROTHIAZIDE 125 MG;
HYDROCHLOROTHIAZIDE .25 MG | - 160. C element
- [common nonmetallic tetrad element with atomic symbol C, atomic number 6, and atomic weight 12.011; defining element of organic compounds. ( CSP )] (UMLS (CSP) C0007009) =Element, Ion, or Isotope =Element;
=charcoal;
|
- 111. 6-Chloro-9-((4-(diethylamino)-1-methylbutyl)amino)-2-methoxyacridine Dihydrochloride
- [The dihydrochloride salt of quinacrine, a 9-aminoacridine derivative, with potential antineoplastic property in addition to its antiparasitic activity. Quinacrine may exert its antineoplastic activity by inhibiting the transcription and activity of both basal and inducible nuclear factor-kappaB (NF-kappaB). Continuous NF-kappaB signaling, as present in many tumors as well as during chronic inflammation, promotes the expression of anti-apoptotic proteins and cytokines while suppressing the expression of pro-apoptotic proteins, such as p53, thereby inhibiting apoptosis and inducing proliferation. The repression of NF-kappaB by quinacrine leads to an induction of the transcription of the tumor suppressor p53. The activation of p53 restores p-53-dependent apoptotic pathways and potentially leads to an inhibition of tumor cell growth. ( NCI )] (UMLS (NCI) C0949411) Atabrine Dihydrochloride;
Mepacrine Dihydrochloride;
Quinacrine Dihydrochloride;
Quinacrine Hydrochloride;
SN 390 =Organic Chemical; Pharmacologic Substance | - 161. c erbA
- [ ] (UMLS (CSP) C0242989) =Gene or Genome ;
|
- 112. 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]-3,4-dihydro-2(1H)-quinolinone
- [A quinolinone derivative and cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III (PDE III). Although the exact mechanism of action of is unknown, cilostazol and its metabolites appears to inhibit PDE III activity, thereby suppressing cyclic adenosine monophosphate (cAMP) degradation. This results in an increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. ( NCI )] (UMLS (NCI) C0055729) =Organic Chemical; Pharmacologic Substance ;
=Tetrazoles;
[CV900] CARDIOVASCULAR AGENTS, OTHER =CILOSTAZOL 100 MG;
CILOSTAZOL 50 MG;
| - 162. c erbB
- [ ] (UMLS (CSP) C0599898) =Gene or Genome ;
|
- 113. 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one
- [benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action; its actions are mediated by enhancement of amma-aminobutyric acid activity; it is used in the treatment of severe anxiety disorders, as a hypnotic in the short-term management of insomnia, as a sedative and premedicant, as an anticonvulsant, and in the management of alcohol withdrawal syndrome. ( CSP )] (UMLS (NCI) C0012010) =Organic Chemical; Pharmacologic Substance =[CN400] ANTICONVULSANTS;
benzodiazepine;
Benzodiazepinones;
[CN300] SEDATIVES/HYPNOTICS;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS;
=DIAZEPAM 10 MG;
DIAZEPAM 15 MG;
DIAZEPAM 2 MG;
DIAZEPAM 5 MG/ML;
Diazepam 1 MG/ML;
DIAZEPAM 5 MG;
DIAZEPAM 2.5 MG;
DIAZEPAM 20 MG | - 163. C fiber
- [unmyelinated sensory axons in peripheral nerves which carry slow pain responses; attached nociceptors are thought to be activated by a chemical released into the extracellular fluid as a result of tissue damage; widely distributed in deep tissue as well as skin. ( CSP )] (UMLS (CSP) C0006549) =Body Part, Organ, or Organ Component ;
=somatic afferent nerve;
|
- 114. 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide
- [A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis. ( NCI )] (UMLS (NCI) C0011276) =Organic Chemical; Antibiotic =[AM250] TETRACYCLINES;
=7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride;
| - 164. c fms
- [ ] (UMLS (CSP) C0079053) =Gene or Genome
|
- 115. 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
- [The hydrochloride salt form of demeclocycline, a broad-spectrum, tetracycline derivative exhibiting antimicrobial activity. Demeclocycline hydrochloride binds reversibly to the 30S ribosomal subunit, thereby blocking the binding of aminoacyl-tRNA to the A-site of the mRNA-ribosome complex. This inhibits protein synthesis. In addition, this agent inhibits ADH-induced water reabsorption in the kidneys, thereby causing diuresis. ( NCI )] (UMLS (NCI) C0282125) =Organic Chemical; Antibiotic ;
=7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide;
=DEMECLOCYCLINE HYDROCHLORIDE 150 MG;
DEMECLOCYCLINE HYDROCHLORIDE 300 MG;
| - 165. c fos
- [c-FOS protein is a transcription factor critical in regulating the development of the skeleton. c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family. Each protein contains a bZIP domain and a leucine zipper domain. FOS oncoproteins derive from mutated FOS genes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein. (from OMIM 164810 and NCI) ( NCI )] (UMLS (CSP) C0085301) =Amino Acid, Peptide, or Protein; Biologically Active Substance ;
◊ [ ] (UMLS (CSP) C0085940) Gene or Genome ; |
- 116. 7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one
- [7-chloro-5-(2-chlorophenyl)-1, 3-dihydro-3-hydroxy-1,4- benzodiazepin-2-one. ( CSP )] (UMLS (NCI) C0024002) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
Benzodiazepinones;
tranquilizer;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS =LORAZEPAM 1 MG;
LORAZEPAM 2 MG;
LORAZEPAM 2 MG/ML;
LORAZEPAM 0.5 MG;
LORAZEPAM 4 MG/ML | - 166. c fps
- [ ] (UMLS (CSP) C0599897) =Gene or Genome ;
|
- 117. 7-Chloro-7-deoxylincomycin
- [A semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0008947) =Carbohydrate; Antibiotic =LINCOMYCIN;
[AM350] LINCOMYCINS;
[DE752] ANTIACNE AGENTS, TOPICAL;
[GU300] ANTI-INFECTIVES, VAGINAL =7(S)-Chloro-7-deoxylincomycin 2-phosphate;
7-Chloro-7-deoxylincomycin Hydrochloride;
Clindamycin Palmitate Hydrochloride;
| - 167. c int2
- [ ] (UMLS (CSP) C0599903) =Gene or Genome ;
|
- 118. 7-Chloro-7-deoxylincomycin Hydrochloride
- [The hydrochloride salt form of clindamycin, a lincomycin antibiotic with antibacterial activity. Clindamycin hydrochloride exerts its antibacterial effect by binding to the 50S subunits of bacterial ribosomes, thereby interfering with peptidyl transferase activity in the elongation process of protein synthesis. As a result, this agent prevents bacterial cell growth. ( NCI )] (UMLS (NCI) C0282105) =Carbohydrate; Antibiotic ;
=7-Chloro-7-deoxylincomycin;
7(S)-Chloro-7-deoxylincomycin 2-phosphate =CLINDAMYCIN HYDROCHLORIDE 150 MG;
CLINDAMYCIN HYDROCHLORIDE 75 MG;
CLINDAMYCIN HYDROCHLORIDE 300 MG | - 168. c jun
- [This gene plays a critical role in transcriptional regulation and cellular growth. ( NCI )] (UMLS (CSP) C0085942) =Gene or Genome ;
|
- 119. 776C85
- (UMLS (NCI) C0650422) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance ;
| - 169. c JUN kinase
- [ ] (UMLS (CSP) C0872123) =Amino Acid, Peptide, or Protein; Enzyme
|
- 120. 776C85/5-FU
- [A combination tablet of ethynyluracil and fluorouracil. Fluorouracil is an antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Ethynyluracil is an orally-active fluoropyrimidine analog that inhibits dihydropyrimidine dehydrogenase, the rate-limiting enzyme that catabolizes and inactivates 5-fluorouracil in the liver. This may lead to an increase in the bioavailability and, effectiveness of fluorouracil. ( NCI )] (UMLS (NCI) C0393027) =Therapeutic or Preventive Procedure
| - 170. c K ras
- [ ] (UMLS (CSP) C0079061) =Gene or Genome
|
- 121. 776C85/CF/5-FU
- (UMLS (NCI) C0393028) =Therapeutic or Preventive Procedure
| - 171. c kit
- [A protein on the surface of some cells that binds to stem cell factor (a substance that causes certain types of cells to grow). Altered forms of this receptor may be associated with some types of cancer. ( NCI )] (UMLS (CSP) C0072470) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
|
- 122. 8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt
- [A sodium salt form of suramin, a polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. ( NCI )] (UMLS (NCI) C0813205) Sodium Suramin;
Suramin Hexasodium;
Suramin sodium =Organic Chemical; Pharmacologic Substance ;
| - 172. c mas
- [ ] (UMLS (CSP) C0599900) =Gene or Genome ;
|
- 123. 8-Chloro Cyclic AMP
- [A substance that is being studied as an anticancer drug. It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate). ( NCI )] (UMLS (NCI) C0050063) =Nucleic Acid, Nucleoside, or Nucleotide; Pharmacologic Substance
| - 173. c myb
- [ ] (UMLS (CSP) C0751993) =Gene or Genome ;
|
- 124. 8-Chloro-6-(2-fluorophenyl)-1-Methyl- 4H- Imidazo(1,5a)(1,4)Benzodiazepine
- [8-chloro-6-(2-fluorophenyl)-1-methyl- 4H- imidazo(1,5a)(1,4)benzodiazepine; short acting benzodiazepine sedative with high liability for abuse; used for preanesthesia sedation (USP lists as an injectable anesthetic). ( CSP )] (UMLS (NCI) C0026056) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
[CN300] SEDATIVES/HYPNOTICS;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS;
=MIDAZOLAM HYDROCHLORIDE;
| - 174. c new
- [ ] (UMLS (CSP) C0599899) =Gene or Genome ;
|
- 125. 8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine
- [A triazolo-benzodiazepine with anxiolytic, anticonvulsant, hypnotic, and muscle relaxant properties. Estazolam binds to the gamma-aminobutyric acid (GABA) receptor at a site distinct from the inhibitory neurotransmitter GABA binding site in the limbic system of the central nervous system (CNS). This binding leads to an opening of the chloride channels, which allows the flow of chloride ions into the neuron, hyperpolarizes the neuronal membrane, inhibits neuronal firing, and leads to a decrease in neuronal excitability. ( NCI )] (UMLS (NCI) C0014892) =Organic Chemical; Pharmacologic Substance =benzodiazepine;
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS =ESTAZOLAM 1 MG;
ESTAZOLAM 2 MG | - 175. C pylori
- [ ] (UMLS (CSP) C0599792) =Bacterium ;
|
- 126. 9,11-Conjugated Linoleic Acid
- [A slightly altered form of linoleic acid, which is an omega-6 fatty acid important to human health. It is found in beef and dairy fats. ( NCI )] (UMLS (NCI) C0050156) =Lipid ;
| - 176. C reactive protein
- [C-reactive protein [precursor] (224 aa, ~25 kDa) is encoded by the CRP gene. This protein is cleaved during biological activation and is associated with host defense mechanisms and inflammatory responses. ( NCI )] (UMLS (CSP) C0006560) =Amino Acid, Peptide, or Protein; Immunologic Factor ;
=acute phase protein;
|
- 127. 9-Chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate
- [A glucocorticoid receptor agonist with metabolic, anti-inflammatory, and immunosuppressive activity. Clocortolone pivalate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. ( NCI )] (UMLS (NCI) C0055900) =Steroid; Pharmacologic Substance; Hormone =Fluocortolone;
CLOCORTOLONE =CLOCORTOLONE PIVALATE 0.1 % | - 177. C Reactive Protein
- [A quantitative measurement of the amount of C-reactive protein present in a sample. ( NCI )] (UMLS (NCI) C0201657) =Laboratory Procedure
|
- 128. 9-cis-Retinoic Acid/Interferon Alfa
- [A combination drug therapy. ( NCI )] (UMLS (NCI) C0338247) =Therapeutic or Preventive Procedure
| - 178. c sis
- [This gene is involved in cellular growth and proliferation. It is also plays a role in intercellular signaling. ( NCI )] (UMLS (CSP) C0751995) PDGFB;
PDGFB Gene;
Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (v-sis) Oncogene Homolog) Gene =Gene or Genome ;
|
- 129. 9-cis-Retinoic Acid/Tamoxifen
- (UMLS (NCI) C0338279) =Therapeutic or Preventive Procedure ;
| - 179. c src
- [This gene is involved in apoptosis, hormonogenesis, focal adhesion and the formation of intercellular junctions. ( NCI )] (UMLS (CSP) C0079073) =Gene or Genome ◊ [CSK is a novel cytoplasmic tyrosine kinase that down regulates the tyrosine kinase activity of c-src oncoprotein through phosphorylation of the c-src carboxy terminus. Since cell transformation by SRC oncoproteins is caused by mechanisms that interfere with this phosphorylation, CSK might function as an antioncogene. The CSK gene is ubiquitously expressed. The SH3 domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells. This association is highly specific; PEP may be an effector and/or regulator of CSK in T-cells and other hemopoietic cells. (from OMIM 124095 and NCI) ( NCI )] (UMLS (CSP) C0138965) Amino Acid, Peptide, or Protein; Enzyme ;
|
- 130. 908
- [The calcium salt form of fosamprenavir, prodrug of amprenavir, and a human immunodeficiency virus (HIV) protease inhibitor with antiviral property. Fosamprenavir is converted to amprenavir by cellular phosphatases in the epithelial cells of the intestine. Then amprenavir binds to the active site of HIV-1 protease, thereby preventing the proteolytic cleavage of viral Gag-Pol polypeptide into individual functional proteins, thereby leading to the formation of immature non-infectious viral particles. ( NCI )] (UMLS (NCI) C1321660) Fosamprenavir Calcium =Organophosphorus Compound; Pharmacologic Substance
| - 180. C(1)-C(4) level spinal cord injury, unspecified
- [ ] (UMLS (ICD9CM) C0161416) =Injury or Poisoning
|
- 131. C
- [Maxillary right primary canine ( HL7V3.0 )] (UMLS (HL7) C0227087) =Body Part, Organ, or Organ Component =Primary dentition;
| - 181. C(1)-C(4) level with central cord syndrome
- [ ] (UMLS (ICD9CM) C0161419) =Injury or Poisoning
|
- 132. c
- [Used to indicate the presence of something or someone. ( NCI )] (UMLS (NCI) C0332287) =Qualitative Concept
| - 182. C(1)-C(4) level with complete lesion of spinal cord
- [ ] (UMLS (ICD9CM) C0161417) =Injury or Poisoning
|
- 133. C
- [A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin. (NCI) ( NCI )] (UMLS (NCI) C0439237) =Quantitative Concept =UnitOfMeasureAtomInsens;
UnitOfMeasureAtomSens | - 183. C(1)-C(4) level with other specified spinal cord injury
- [ ] (UMLS (ICD9CM) C0161420) =Injury or Poisoning
|
- 134. C & S NEC
- [ ] (UMLS (ICD9CM) C0177983) =Laboratory Procedure
| - 184. C(1)-C(4) quadriplegia and quadriparesis, complete
- [ ] (UMLS (ICD9CM) C0376129) =Disease or Syndrome
|
- 135. C & S NOS
- [ ] (UMLS (ICD9CM) C0177990) =Laboratory Procedure
| - 185. C(1)-C(4) quadriplegia and quadriparesis, incomplete
- [ ] (UMLS (ICD9CM) C0376130) =Disease or Syndrome
|
- 136. C & S-BILI/PANCREAS
- [ ] (UMLS (ICD9CM) C0177919) =Laboratory Procedure
| - 186. C(5)-C(7) level spinal cord injury, unspecified
- [ ] (UMLS (ICD9CM) C0161421) =Injury or Poisoning
|
- 137. C & S-BLOOD
- [ ] (UMLS (ICD9CM) C0177879) =Laboratory Procedure
| - 187. C(5)-C(7) level with central cord syndrome
- [ ] (UMLS (ICD9CM) C0161424) =Injury or Poisoning
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- 138. C & S-ENDOCRINE
- [ ] (UMLS (ICD9CM) C0302458) =Laboratory Procedure
| - 188. C(5)-C(7) level with complete lesion of spinal cord
- [ ] (UMLS (ICD9CM) C0161422) =Injury or Poisoning
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- 139. C & S-ENT/LARYNX
- [ ] (UMLS (ICD9CM) C0177863) =Laboratory Procedure
| - 189. C(5)-C(7) level with other specified spinal cord injury
- [ ] (UMLS (ICD9CM) C0161425) =Injury or Poisoning
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- 140. C & S-EYE
- [ ] (UMLS (ICD9CM) C0177855) =Laboratory Procedure
| - 190. C(5)-C(7) quadriplegia and quadriparesis, complete
- [ ] (UMLS (ICD9CM) C0376131) =Disease or Syndrome
|
- 141. C & S-FEMALE GENITAL
- [ ] (UMLS (ICD9CM) C0177951) =Laboratory Procedure
| - 191. C(5)-C(7) quadriplegia and quadriparesis, incomplete
- [ ] (UMLS (ICD9CM) C0376132) =Disease or Syndrome
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- 142. C & S-INTEGUMENT
- [ ] (UMLS (ICD9CM) C0177967) =Laboratory Procedure
| - 192. C-52
- [A member of the cryptophycin family of antitumor agents that binds to microtubules, inducing growth arrest and apoptosis in solid tumors. (NCI) ( NCI )] (UMLS (NCI) C0756544) Cryptophycin 52;
Cyclo[2,2-dimethyl-.beta.-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyloxiranyl]-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl] =Organic Chemical; Pharmacologic Substance |
- 143. C & S-LOWER GI
- [ ] (UMLS (ICD9CM) C0177911) =Laboratory Procedure
| - 193. C-C Chemokine Receptor D6
- [Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa, hemopoietic cells, and fetal liver by human CCBP2 Gene (GPCR1/Beta Chemokine Receptor Family), Chemokine (C-C Motif) Receptor 9 is a seven transmembrane G protein-coupled receptor for many beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and is critical for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes. (NCI) ( NCI )] (UMLS (NCI) C1332648) C-C Chemokine Receptor Type 9;
CCBP2;
CC-Chemokine Receptor CCR10;
CC-Chemokine-Binding Receptor JAB61;
CCR10;
CCR9;
CCR-9;
Chemokine (C-C Motif) Receptor 9;
Chemokine Binding Protein 2;
Chemokine-Binding Protein D6;
CMBRK9;
D6;
hD6 =Amino Acid, Peptide, or Protein; Receptor |
- 144. C & S-LOWER RESP
- [ ] (UMLS (ICD9CM) C0177871) =Laboratory Procedure
| - 194. C-C Chemokine Receptor Type 11
- [Chemokine (C-C Motif) Receptor-Like 1, a 45-kD glycosylated protein encoded by the CCRL1 gene, is a G protein-coupled receptor that binds chemokines of the CC subfamily, especially MCP-4, ELC (SCYA19) and TECK (SCYA25). CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. Predominant expression of 5.0, 2.0 and 1.3kb mRNA forms exist in human heart tissue, while low-level expression of the 2.0 and 1.3kb forms in lung, pancreas and spleen and in fetal tissues. The CCRL1 gene has one intron in the 5' untranslated region. (From LocusLink, OMIM, and NCI) ( NCI )] (UMLS (NCI) C0914305) C-C CKR-11;
CCBP2;
CC-CKR-11;
CCR11;
CCR-11;
CCRL1;
CCRL1 Protein;
CCX CKR;
CCX-CKR;
Chemokine (C-C Motif) Receptor-Like 1;
Chemokine Receptor-Like 1;
PPR1;
PPR1, Bovine, Homolog of;
VSHK1 =Amino Acid, Peptide, or Protein; Receptor ;
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- 145. C & S-LOWER URINARY
- [ ] (UMLS (ICD9CM) C0177943) =Laboratory Procedure
| - 195. C-C Chemokine Receptor Type 5
- [Chemokine (C-C Motif) Receptor 5, encoded by the CCR5 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C0387687) =Amino Acid, Peptide, or Protein; Immunologic Factor; Receptor
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- 146. C & S-LYMPH SYSTEM
- [ ] (UMLS (ICD9CM) C0177895) =Laboratory Procedure
| - 196. C-C Chemokine Receptor Type 9
- [Differentially expressed in T lymphocytes in small intestine and colon as well as in thymus, lymph nodes, and spleen as two variants by human CCR9 Gene (GPCR1/Beta Chemokine Receptor Family), C-C Chemokine Receptor Type 9 is a seven transmembrane G protein-coupled receptor and regulator of thymocyte migration/recruitment and development that may promote specialization of immune responses and inflammation in different regions of the gastrointestinal tract. CCR9 mediates intracellular calcium flux and specifically binds to CC chemokine TECK/CCL25 ligand. (From LocusLink and NCI) ( NCI )] (UMLS (NCI) C1332645) CCR9;
CCR-9;
Chemokine (C-C Motif) Receptor 9;
GPR-9-6;
=Amino Acid, Peptide, or Protein; Receptor |
- 147. C & S-MUSCULOSKELETAL
- [ ] (UMLS (ICD9CM) C0177959) =Laboratory Procedure
| - 197. C-Cell
- [A neuroendocrine cell found in the thyroid gland interspersed among the follicular cells or in clusters between the follicles. It produces and secretes calcitonin in response to its calcium receptor. ( NCI )] (UMLS (NCI) C0229579) =Cell
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- 148. C & S-NERVOUS SYST
- [ ] (UMLS (ICD9CM) C0177839) =Laboratory Procedure
| - 198. C-Cell Hyperplasia
- (UMLS (NCI) C1392158) =Pathologic Function ;
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- 149. C & S-OP WOUND
- [ ] (UMLS (ICD9CM) C0177975) =Laboratory Procedure
| - 199. C-ERBA-ALPHA-1
- [A high-affinity thyroid hormone receptor expressed in many tissues, with highest levels in the central nervous system. ( NCI )] (UMLS (NCI) C0919489) ERBA-Alpha Protein;
ERBA-Related Protein 7;
THRA;
THRA Protein;
Thyroid Hormone Receptor Alpha-1 =Amino Acid, Peptide, or Protein; Receptor |
- 150. C & S-PERITONEUM
- [ ] (UMLS (ICD9CM) C0177927) =Laboratory Procedure
| - 200. c-erbB-1
- [Epidermal growth factor receptor. The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor. ( NCI )] (UMLS (NCI) C0034802) =Amino Acid, Peptide, or Protein; Enzyme; Receptor
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