UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
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A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
selected terms: 70,266 page 2 of 703

101. (17Beta)-17-hydroxy-17-methylandrost-4-en-3-one
[A methylated synthetic androgen receptor agonist with anabolic effects. Methyltestosterone, mimicking testosterone, binds to cytosolic androgen receptors, and the subsequent nuclear transfer of the ligand-receptor complex induces transcription initiation of androgen responsive genes. The gene products are responsible for normal growth and development of male sex organs and secondary sex characteristics. The agent also causes retention of nitrogen, sodium, potassium, phosphorus, as well as calcium. ( NCI )] (UMLS (NCI) C0025826) =Steroid; Pharmacologic Substance; Hormone =(17Beta)-17-hydroxyandrost-4-en-3-one;
[HS100] ANDROGENS/ANABOLICS =METHYLTESTOSTERONE POWDER (GM);
METHYLTESTOSTERONE 1.25 MG;
METHYLTESTOSTERONE 2.5 MG;
METHYLTESTOSTERONE 25 MG;
METHYLTESTOSTERONE 5 MG;
METHYLTESTOSTERONE 10 MG;
151. (3beta)-Stigmast-5-en-3-ol
(UMLS (NCI) C0106127) =Steroid; Pharmacologic Substance
102. (17Beta)-17-hydroxyandrost-4-en-3-one
[major androgenic hormone produced by the Leydig cells of the testes. ( CSP )] (UMLS (NCI) C0039601) =Steroid; Pharmacologic Substance; Hormone =androgen;
Androstenols;
[HS100] ANDROGENS/ANABOLICS;
=(17Beta)-17-hydroxy-17-methylandrost-4-en-3-one;
(17beta)-17-(1-Oxopropoxy)androst-4-en-3-one;
17Beta-Cyclopentanepropionate;
Testosterone enanthate;
(17beta)-17-(1-Oxopropoxy)androst-4-en-3-one;
17Beta-Cyclopentanepropionate;
Testosterone enanthate;
TESTOSTERONE POWDER (GM);
TESTOSTERONE 100 MG/ML;
TESTOSTERONE 25 MG;
TESTOSTERONE 25 MG/ML;
TESTOSTERONE 75 MG;
TESTOSTERONE 50 MG/ML;
TESTOSTERONE 5 GM;
TESTOSTERONE 2.5 GM;
TESTOSTERONE 4 MG;
TESTOSTERONE 6 MG;
TESTOSTERONE 2.5 MG;
TESTOSTERONE 5 MG
152. (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester
[alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative. ( CSP )] (UMLS (NCI) C0035179) =Organic Chemical; Pharmacologic Substance =rauwolfia alkaloid;
tranquilizer;
[CV490] ANTIHYPERTENSIVES, OTHER;
=RESCINNAMINE;
DESERPIDINE;
RESERPINE 0.25 MG;
RESERPINE 0.1 MG;
RESERPINE 0.125 MG
103. (17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol
[2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors. It prevents the formation of new blood vessels that tumors need in order to grow. ( NCI )] (UMLS (NCI) C0046319) =Steroid; Pharmacologic Substance
153. (3beta,20beta)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic Acid
[A widely used anti-inflammatory agent isolated from the licorice root. It is metabolized to GLYCYRRHETINIC ACID, which inhibits 11-BETA-HYDROXYSTEROID DEHYDROGENASES and other enzymes involved in the metabolism of CORTICOSTEROIDS. Therefore, glycyrrhizic acid, which is the main and sweet component of licorice, has been investigated for its ability to cause hypermineralocorticoidism with sodium retention and potassium loss, edema, increased blood pressure, as well as depression of the renin-angiotensin-aldosterone system. ( MSH )] (UMLS (NCI) C0061751) =Organic Chemical; Pharmacologic Substance ;
104. (17beta)-Estra-1,3,5(10)-triene-3,17-diol
[generally refers to the 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position; estradiol-17-beta is the most potent form of mammalian estrogenic steroids. ( CSP )] (UMLS (NCI) C0014912) =Steroid; Pharmacologic Substance; Hormone =(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
Estrenes;
[HS300] ESTROGENS;
[GU500] ESTROGENS, VAGINAL =17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate];
17beta-Estradiol 17-Cyclopentylpropionate;
ESTRADIOL VALERATE;
Estradiol Phosphate Polymer;
ESTRADIOL 17-BETA 1 MG;
(17beta)-Estra-1,3,5(10)-triene-3,17-diol;
17beta-Estradiol 17-Cyclopentylpropionate;
ESTRADIOL VALERATE;
84 HR Estradiol 0.00156 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00312 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00417 MG/HR Transdermal Patch [Vivelle-Dot];
84 HR Estradiol 0.00208 MG/HR Transdermal Patch [Vivelle-Dot];
ESTRADIOL MISC. POWDER (GM);
ESTRADIOL 0.5 MG;
ESTRADIOL 1 MG;
ESTRADIOL 2 MG;
ESTRADIOL 0.025 MG;
84 HR Estradiol 0.00104 MG/HR Transdermal Patch [Vivelle-Dot];
ESTRADIOL 0.01 %;
ESTRADIOL 0.0375 MG;
ESTRADIOL 0.05 MG;
ESTRADIOL 0.075 MG;
ESTRADIOL 0.1 MG;
ESTRADIOL 25 MCG
154. (3beta,20beta)-3-(3-Carboxy-1-oxopropoxy)-11-oxoolean-12-en-29-oic Acid
[An agent derived from licorice root. It is used for the treatment of digestive tract ulcers, especially in the stomach. Antidiuretic side effects are frequent, but otherwise the drug is low in toxicity. ( MSH )] (UMLS (NCI) C0006979) =Steroid; Pharmacologic Substance
105. (17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-Benzoate
[The synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04) ( NCI )] (UMLS (NCI) C0167626) =Steroid; Pharmacologic Substance; Hormone
155. (3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid
[An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation. ( MSH )] (UMLS (NCI) C0017986) =Organic Chemical; Pharmacologic Substance
106. (17beta)-Estra-1,3,5(10)-triene-3,17-diol Dipropanoate
[The synthetic dipropionate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females. As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors. This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04) ( NCI )] (UMLS (NCI) C0059618) =Steroid; Pharmacologic Substance; Hormone
156. (3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
[A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels. In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI) ( NCI )] (UMLS (NCI) C0012258) =Steroid; Carbohydrate; Pharmacologic Substance; Biologically Active Substance =cardenolide;
[CV050] DIGITALIS GLYCOSIDES
107. (1alpha,2alpha,3beta,4alpha,5alpha,6beta)1,2,3,4,5,6-Hexachlorocyclohexane
[gamma isomer of benzene hexachloride, a carcinogenic insecticide more potent than DDT (chlorophenothane); it is used to kill lice and mites, applied topically to the skin. ( CSP )] (UMLS (NCI) C0005038) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
157. (3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol
[produced in human and other animal tissue by photoactivation (normally sunlight on skin) of 7-dehydrocholesterol. ( CSP )] (UMLS (NCI) C0008318) =Steroid; Pharmacologic Substance; Vitamin =Cholestenes;
Secosteroids;
sterol;
[VT500] VITAMIN D;
[VT509] VITAMIN D, OTHER;
TO BE DELETED INGREDIENT PREPARATIONS =Hydroxycholecalciferols;
CHOLECALCIFEROL/FISH LIVER OIL OINT,TOP;
CRITICARE HN LIQUID;
THICKENUP POWDER;
ULTRACAL TUBE-FEEDING LIQUID;
CHOLECALCIFEROL 133 UNT;
CHOLECALCIFEROL 400 IU;
CHOLECALCIFEROL 400 UNT/ML;
108. (1alpha,3beta,5Z,7E)-9,10-Secocholesta-3,7,10(19),16-tetraene-1,3,25-triol
(UMLS (NCI) C0255545) =Steroid; Pharmacologic Substance ;
158. (3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol
[Lutein (LOO-teen) is a oxygenated carotenoid found in vegetables and fruits. lutein is found in the macula of the eye, where it is believed to act as a yellow filter. Lutein acts as an antioxidant, protecting cells against the damaging effects of free radicals. ( NCI )] (UMLS (NCI) C0043328) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
109. (1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol
[most biologically active metabolite of cholecalciferol; acts via a DNA-binding steroid receptor which induces transcription of calcium transport factors in gut; USP drug (calcitriol) is given as an antihypocalcemic. ( CSP )] (UMLS (NCI) C0006674) =Steroid; Pharmacologic Substance; Hormone; Vitamin =(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol;
Dihydroxycholecalciferols;
[VT500] VITAMIN D;
steroid hormone =Calcipotriene;
(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol;
Calcitriol 0.00025 MG;
Calcitriol 0.0005 MG;
Calcitriol 0.001 MG/ML;
Calcitriol 0.002 MG/ML
159. (3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate
(UMLS (NCI) C0081489) =Organic Chemical; Pharmacologic Substance
110. (1alpha,3beta,5Z,7E)-9,10-Secostigmasta-5,7,10(19)-triene-1,3-diol
(UMLS (NCI) C0534957) =Steroid ;
160. (3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
[A fungal toxin produced by various species of Trichoderma, Gladiocladium fimbriatum, Aspergillus fumigatus, and Penicillium. It is used as an immunosuppressive agent. ( MSH )] (UMLS (NCI) C0017641) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
111. (1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
[A substance that is being studied in the prevention of recurrent prostate cancer. It belongs to the family of drugs called vitamin D analogs. ( NCI )] (UMLS (NCI) C0043668) =Steroid; Pharmacologic Substance; Vitamin =Ergocalciferols;
[VT509] VITAMIN D, OTHER =Doxercalciferol 0.002 MG/ML;
DOXERCALCIFEROL 0.0025 MG;
161. (3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid
[The sodium salt of a synthetic lipid-lowering agent with potential antineoplastic properties. Fluvastatin competitively inhibits hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses through the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated antigen-presenting cells such as human vascular endothelial cells. Due to its anti-inflammatory effects mediated by alterations of lipid metabolism, fluvastatin may possess chemopreventive and therapeutic antineoplastic properties. ( NCI )] (UMLS (NCI) C0246203) =Organic Chemical; Pharmacologic Substance ;
=FLUVASTATIN;
=FLUVASTATIN SODIUM 20 MG;
FLUVASTATIN SODIUM 40 MG;
FLUVASTATIN SODIUM 80 MG
112. (1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-Tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione
[A macrocyclic antifungal antibiotic that inhibits signal-dependent transcriptional activation and induces differentiation in leukemia. (NCI) ( NCI )] (UMLS (NCI) C0207800) =Organic Chemical; Pharmacologic Substance ;
162. (3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide
[An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Prinomastat is a matrix metalloproteinase inhibitor. Also called AG3340. ( NCI )] (UMLS (NCI) C0919273) AG3340;
Pinomastat;
Prinomastat;
Prinomastat/AG 3340 =Organic Chemical; Pharmacologic Substance ;
113. (1aS,8S,8aR,8bS)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione
[antineoplastic antibiotic produced by Streptomyces caespitosus that acts as an alkylating agent causing cross-linking of DNA and inhibition of DNA synthesis. ( CSP )] (UMLS (NCI) C0002475) =Organic Chemical; Antibiotic
163. (3S,3'S)-3,3'-Dihydroxy-beta,beta-carotene-4,4'-dione
(UMLS (NCI) C0052565) =Organic Chemical; Biologically Active Substance
114. (1H-Indol-3-ylmethyl)carbamodithioic Acid, Methyl Ester
(UMLS (NCI) C0258434) =Organic Chemical; Pharmacologic Substance
164. (4-Amino-1-hydroxybutylidene)bisphosphonic Acid
[bone resorption inhibitor. ( CSP )] (UMLS (NCI) C0102118) =Organophosphorus Compound; Pharmacologic Substance ;
=inhibitor/antagonist;
biphosphonate;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
=ALENDRONATE 70 MG;
ALENDRONATE 35 MG;
ALENDRONATE 10 MG;
ALENDRONATE 5 MG;
ALENDRONATE 40 MG;
115. (1R,2R)-2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium Benzenesulfonate, Pentamethylene Ester
[A non-depolarizing skeletal muscle relaxant of the benzylisoquinolinium class. Cisatracurium besylate acts as a competitive acetylcholine antagonist that binds to nicotinic receptors at the neuromuscular junction. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is used to maintain neuromuscular relaxation during major surgical procedures, primarily to facilitate endotracheal intubation. Cisatracurium besylate can cause bronchospasms, hypotension, and bradycardia. ( NCI )] (UMLS (NCI) C0530105) =Organic Chemical; Pharmacologic Substance ;
=Atracurium;
CISATRACURIUM =CISATRACURIUM BESYLATE 10 MG/ML;
CISATRACURIUM BESYLATE 2 MG/ML;
165. (4-carboxyphthalato)(1,2-diaminocyclohexane)-platinum(II)
[A second-generation platinum analog with potential antineoplastic activity. Dacplatinum alkylates DNA at the N-7 position of guanine, thereby producing DNA interstrand crosslinks and DNA strand breaks, and inhibiting DNA replication. (NCI04) ( NCI )] (UMLS (NCI) C0054768) =Organic Chemical; Pharmacologic Substance ;
116. (1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)
[The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05) ( NCI )] (UMLS (NCI) C0543454) =Organophosphorus Compound; Antibiotic ;
=FOSFOMYCIN;
1,3-Propanediol, 2-Amino-2-(hydroxymethyl)- =FOSFOMYCIN TROMETHAMINE 3 GM
166. (4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
[A synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04) ( NCI )] (UMLS (NCI) C0077144) =Steroid; Pharmacologic Substance =Stanolone;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
TO BE DELETED INGREDIENT PREPARATIONS;
=TRILOSTANE 60 MG;
TRILOSTANE 30 MG;
117. (1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,2
[A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05) ( NCI )] (UMLS (NCI) C0541315) =Organic Chemical; Pharmacologic Substance
167. (4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide Mono(5-sulfosalicylate)(Salt)
[The sulfosalicylate salt form of meclocycline, a tetracycline antibiotic with broad-spectrum antibacterial and antiprotozoal activity. Meclocycline sulfosalicylate is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative bacteria. ( NCI )] (UMLS (NCI) C0700494) =Organic Chemical; Antibiotic ;
118. (1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol
[A vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer. Mediated through vitamin D receptor, this agent induces cancer cell differentiation, inhibits cancer cell growth and induces apoptosis. In addition, seocalcitol may also induce growth arrest and apoptosis independent of vitamin D receptor activation through mechanisms that are not fully elucidated. ( NCI )] (UMLS (NCI) C0905598) 1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene;
Seocalcitol =Organic Chemical; Pharmacologic Substance ;
168. (4S,4aR,5S,5aR,6S,12aS)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide, Monohydrochloride
[The hydrochloride salt form of oxytetracycline, a tetracycline derivative produced by Streptomyces rimosus exhibiting antimicrobial activity. Oxytetracycline hydrochloride interferes with binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby preventing peptide elongation and inhibiting protein synthesis. It is often used to treat skin conditions. ( NCI )] (UMLS (NCI) C0017449) =Organic Chemical; Antibiotic ;
=OXYTETRACYCLINE;
=OXYTETRACYCLINE 50 MG/ML;
OXYTETRACYCLINE HYDROCHLORIDE 500 MG;
OXYTETRACYCLINE HYDROCHLORIDE 100 MG;
OXYTETRACYCLINE HYDROCHLORIDE 125 MG;
OXYTETRACYCLINE HYDROCHLORIDE 250 MG;
OXYTETRACYCLINE HYDROCHLORIDE 30 MG/GM;
OXYTETRACYCLINE HYDROCHLORIDE 0.5 %;
119. (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside
[An anticancer drug that belongs to the family of drugs called antitumor antibiotics. Also called 4-demethoxydaunorubicin. ( NCI )] (UMLS (NCI) C0020789) =Organic Chemical; Pharmacologic Substance ;
=antineoplastic antibiotics;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione =Idarubicin HCl;
169. (4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride
[The hydrochloride salt form of tetracycline, a broad-spectrum naphthacene antibiotic, produced semisynthetically from chlortetracycline, an antibiotic isolated from the Streptomyces aureofaciens. In bacteria, tetracycline hydrochloride blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis and bacterial cell growth. ( NCI )] (UMLS (NCI) C0546879) =Organic Chemical; Antibiotic =4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide;
[DE752] ANTIACNE AGENTS, TOPICAL;
[OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC;
=TETRACYCLINE HYDROCHLORIDE 56 X 500 MG;
TETRACYCLINE HYDROCHLORIDE 125 MG/5ML;
TETRACYCLINE HYDROCHLORIDE 250 MG;
TETRACYCLINE HYDROCHLORIDE 500 MG;
TETRACYCLINE HYDROCHLORIDE 2.2 MG/ML;
TETRACYCLINE HYDROCHLORIDE 1 %;
TETRACYCLINE HYDROCHLORIDE 250 MG/ML;
TETRACYCLINE HYDROCHLORIDE 100 MG;
TETRACYCLINE HYDROCHLORIDE 3 %;
TETRACYCLINE HYDROCHLORIDE 100 MG/ML;
120. (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione
[An enteric-coated formulation of ixabepilone, a semisynthetic analogue of epothilone B and a non-taxane tubulin inhibitor, with antineoplastic activity. Ixabepilone binds to and stabilizes tubulin molecules, thereby interfering with the dynamics of microtubule assembly/disassembly. This results in cell cycle arrest at G2-M phase and leads to apoptosis of fast growing tumor cells. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. Compared to intravenously administered ixabepilone, the oral formulation is a less cumbersome way of administering this agent. ( NCI )] (UMLS (NCI) C1135132) Azaepothilone B;
Epothilone;
IXABEPILONE;
Oral Ixabepilone =Organic Chemical; Pharmacologic Substance ;
170. (4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione
[A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. (NCI04) ( NCI )] (UMLS (NCI) C0962559) 12,13-Deoxyepothilone B;
Desoxyepothilone B;
Epothilone D;
=Organic Chemical; Pharmacologic Substance ;
121. (1Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic Acid, 4-(Nitrooxy)butyl Ester
(UMLS (NCI) C0968094) Nitrosulindac;
NO-Releasing Sulindac;
=Organic Chemical; Pharmacologic Substance ;
171. (5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester
[A synthetic benzimidazole derivate and anthelmintic agent. Mebendazole interferes with the reproduction and survival of helminths by inhibiting the formation of their cytoplasmic microtubules, thereby selectively and irreversibly blocking glucose uptake. This results in a depletion of glycogen stores and leads to reduced formation of ATP required for survival and reproduction of the helminth. This eventually causes the helminths death. ( NCI )] (UMLS (NCI) C0025023) =Organic Chemical; Pharmacologic Substance ;
=Anthelminthics;
benzimidazole =MEBENDAZOLE 100 MG
122. (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid
[The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties. Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins. This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis. The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04) ( NCI )] (UMLS (NCI) C0075615) =Organic Chemical; Pharmacologic Substance
172. (5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one Hydrochloride
[The hydrochloride salt form of naltrexone, a noroxymorphone derivative with competitive opioid antagonistic property. Naltrexone reverses the effects of opioid analgesics by binding to the various opioid receptors in the central nervous system, including the mu-, kappa- and gamma-opioid receptors. This leads to an inhibition of the typical actions of opioid analgesics, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia, and physical dependence. Naltrexone is longer-acting and more potent compared to naloxone. ( NCI )] (UMLS (NCI) C0355800) =Organic Chemical; Pharmacologic Substance =NALTREXONE;
=NALTREXONE HYDROCHLORIDE 50 MG
123. (2'R,3S,3'R,3'aS,6'S,6aS,6bS,7'aR,11aS,11bR)-1,2,3,3'a,4,4',5',6,6',6a,6b,7,7',7'a,8,11,11a,11b-Octadecahydro-3',6',10,11b-tetramethylspiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b
(UMLS (NCI) C0056789) =Organic Chemical ;
173. (5alpha,17beta)-17-Hydroxyandrostan-3-one
[potent androgenic metabolite of testosterone; dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone; unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. ( CSP )] (UMLS (NCI) C0038148) =Steroid; Pharmacologic Substance; Hormone =androgen;
Androstanols =(4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile
124. (2"R)-4'-O-Tetrahydropyranyladriamycin
[An analogue of the anthracycline antineoplastic antibiotic doxorubicin. Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (NCI04) ( NCI )] (UMLS (NCI) C0071126) =Organic Chemical; Pharmacologic Substance ;
174. (5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
[orally active testosterone 5-alpha reductase inhibitor, used as an alternative to surgery for treatment of benign prostatic hyperplasia. ( CSP )] (UMLS (NCI) C0060389) =Steroid; Pharmacologic Substance ;
=Androstenes;
[AN000] ANTINEOPLASTICS;
Azasteroids;
enzyme inhibitor;
[HS900] HORMONES/SYNTHETICS/MODIFIERS, OTHER;
=FINASTERIDE 1 MG;
FINASTERIDE 5 MG
125. (2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)
[An anticancer drug that belongs to the family of drugs called antimetabolites. ( NCI )] (UMLS (NCI) C0053902) =Organic Chemical; Pharmacologic Substance ;
175. (5alpha,6alpha)-17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol Hydrochloride
[The hydrochloride salt form of nalbuphine, a synthetic phenanthrene opioid with opiate agonist and antagonist effects, used to treat moderate to severe pain and provide preoperative and postoperative analgesia and sedation. Nalbuphine hydrochloride binds to kappa-, mu- and delta-opioid receptors but not to sigma-opioid receptors. This opioid exerts its analgesic actions primarily through kappa-opioid-receptor agonism and partially through mu-opioid receptor agonism. ( NCI )] (UMLS (NCI) C0600099) =Organic Chemical; Pharmacologic Substance =NALBUPHINE;
=NALBUPHINE HYDROCHLORIDE 20 MG/ML;
NALBUPHINE HYDROCHLORIDE 1.5 MG/ML;
NALBUPHINE HYDROCHLORIDE 10 MG/ML
126. (2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-
[An anticancer drug extracted from the cotton plant. ( NCI )] (UMLS (NCI) C0018096) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
176. (6-D-(2-Naphthyl)alanine)LHRH Acetate
(UMLS (NCI) C0700477) =Amino Acid, Peptide, or Protein; Pharmacologic Substance =6-D-(2-naphthyl)alanyl-GnRH;
=NAFARELIN ACETATE 2 MG/ML;
127. (2-Isothiocyanatoethyl)benzene
[Phenethyl isothiocyanate. A naturally occurring compound found in some cruciferous vegetables. It is being studied as an agent to prevent cancer. ( NCI )] (UMLS (NCI) C0070558) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
177. (6-Isothiocyanatohexyl)benzene
(UMLS (NCI) C0099413) =Organic Chemical; Pharmacologic Substance ;
128. (2-Mercaptoethyl)trimethylammonium Iodide S-ester with O,O-diethyl Phosphorothioate, Diethoxyphosphoryl-thiocholine Iodide
[The iodide salt form of echothiophate, a long-acting cholinesterase inhibitor with parasympathomimetic activity. Echothiophate iodide potentiates the action of endogenous acetylcholine by inhibiting acetylcholinesterase that hydrolyzes acetylcholine. When applied topically to the eye, this agent prolongs stimulation of the parasympathetic receptors at the neuromuscular junctions of the longitudinal muscle of the ciliary body. Contraction of longitudinal muscle pulls on the scleral spur, and opens the trabecular meshwork, thereby increases aqueous humor outflow from the eye and reduces intraocular pressure. ( NCI )] (UMLS (NCI) C0013530) =Organophosphorus Compound; Pharmacologic Substance =Organothiophosphorus Compounds;
ECHOTHIOPHATE =ECHOTHIOPHATE IODIDE 0.03 %;
ECHOTHIOPHATE IODIDE 0.125 %;
ECHOTHIOPHATE IODIDE 0.25 %;
ECHOTHIOPHATE IODIDE 0.06 %;
178. (6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione
[A synthetic, acetate derivative of the sex hormone progesterone. Medroxyprogesterone 17-acetate (NCI04) ( NCI )] (UMLS (NCI) C0065864) =Steroid; Pharmacologic Substance; Hormone =(6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione;
=MEDROXYPROGESTERONE ACETATE 14 TABS X 5 MG;
MEDROXYPROGESTERONE ACETATE DAY15-28 X 5 MG;
MEDROXYPROGESTERONE ACETATE 5 MG;
MEDROXYPROGESTERONE ACETATE 2.5 MG;
MEDROXYPROGESTERONE ACETATE 100 MG/ML;
MEDROXYPROGESTERONE ACETATE 10 MG;
MEDROXYPROGESTERONE ACETATE 25 MG;
MEDROXYPROGESTERONE ACETATE 400 MG/ML;
MEDROXYPROGESTERONE ACETATE 150 MG/ML;
129. (2-Mercaptopropionyl)glycine
[An acylated sulfhydryl-containing derivative of glycine with reducing and complexing properties. Tiopronin breaks the disulphide bond of cystine and binds the sulfhydryl group of the resultant cysteine monomers to form a soluble tiopronin-cysteine-mixed disulfide, which is more water-soluble than cystine and is readily excreted. This leads to a reduction in urinary cystine concentration and subsequently reduces cystine stone formation. ( NCI )] (UMLS (NCI) C0025405) =Amino Acid, Peptide, or Protein; Pharmacologic Substance ;
=Amino Acids, Sulfur;
GLYCINE;
Unclassified Ingredient Preparations;
=Thiopronine 100 MG;
179. (6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
[synthetic progestin derived from 17-hydroxyprogesterone; a long-acting contraceptive that is effective both orally or by intramuscular injection and has also been used to treat breast and endometrial neoplasms. ( CSP )] (UMLS (NCI) C0025147) =Steroid; Pharmacologic Substance; Hormone =[HS800] PROGESTINS;
17alpha-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione;
progesterone analog;
=(6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione
130. (201-Tl) Thallous Chloride
[The chloride salt form of thallium-201, a cyclotron produced isotope use in diagnostic imaging. Thallous chloride TI-201 accumulates in myocardial cells and other tissues in an analogous way as potassium, and can be evaluated as a function of blood flow. By scintigraphic means, areas with decreased blood flow, consisting of ischemic cells, can be visualized due to decreased uptake of TI-201 in contrast to areas with normal blood flow. ( NCI )] (UMLS (NCI) C0305040) =Indicator, Reagent, or Diagnostic Aid; Inorganic Chemical ;
=thallium chloride;
[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS =Thallous chloride Tl201 1 MIL;
Thallous chloride Tl201 1 MIL/ML;
Thallous chloride Tl201 2 MIL/ML;
180. (6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione
[synthetic glucocorticoid derived from progesterone, used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant. ( CSP )] (UMLS (NCI) C0025815) =Steroid; Pharmacologic Substance; Hormone =[HS051] GLUCOCORTICOIDS;
(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione =(7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione;
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate;
METHYLPREDNISOLONE SODIUM SUCCINATE;
11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate;
METHYLPREDNISOLONE SODIUM SUCCINATE;
METHYLPREDNISOLONE 2 MG;
METHYLPREDNISOLONE 24 MG;
METHYLPREDNISOLONE 32 MG;
METHYLPREDNISOLONE 8 MG;
METHYLPREDNISOLONE 16 MG;
METHYLPREDNISOLONE 4 MG
131. (2alpha,3beta)-2,3,23-Trihydroxyurs-12-en-28-oic acid, O-6-deoxy-alpha-L-mannopyranosyl-(1--4)--beta-D-glucopyranosyl-(1--6)-O-beta-D-glucopyranosyl Ester
(UMLS (NCI) C0052506) =Organic Chemical; Pharmacologic Substance
181. (6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
[A synthetic glucocorticoid and derivative of fluocinolone acetonide with anti-inflammatory and antipruritic activity. Fluocinonide binds the glucocorticoid receptor, followed by translocation of the ligand-receptor complex to the nucleus and transcription activation of genes containing glucocorticoid-responsive elements. Lipocortin-1 is one factor induced by fluocinonide that interacts and inhibits cytosolic phospholipase 2 alpha, thereby preventing phospholipase translocation to the perinuclear membrane and subsequent release and conversion of arachidonic acid to inflammatory prostaglandins. In addition, MAPK phosphatase 1 is induced, thereby preventing the triggering of the MAPK cascade resulting in pro-inflammatory effects via Jun N-terminal kinase and c-Jun. Finally, fluocinonide binds to and inhibits nuclear factor kappa-B directly, resulting in inhibition of cyclooxygenase 2 transcription and subsequent prostaglandin synthesis. ( NCI )] (UMLS (NCI) C0016299) =Steroid; Pharmacologic Substance ;
=(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
[DE200] ANTI-INFLAMMATORY, TOPICAL =FLUOCINONIDE 0.05 %
132. (2E)-5-[3-[(Phenylsufonyl) Aminol Phenyl]-pent-2-en-4-ynohydroxamic Acid
[An inhibitor of histone deacetylase. It is an aromatic sulfonamide hydroxamate initially found in a screen for inhibitors of the tumorigenic phenotype of K-ras-transformed NIH3T3 cells. ( NCI )] (UMLS (NCI) C0391491) =Organic Chemical; Pharmacologic Substance ;
182. (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
[The acetonide salt form of fluocinolone, a synthetic fluorinated corticosteroid with antiinflammatory, antipruritic and vasoconstrictive properties. Fluocinolone is a glucocorticoid receptor agonist that binds to cytoplasmic glucocorticoid receptors and subsequently translocates to the nucleus where it initiates the transcription of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both are potent mediators of inflammation. Fluocinolone exerts its vasoconstrictive effect through inhibition of nitric oxide synthase, thereby blocking nitric oxide production and effectively diminishing the effect of nitric oxide on vascular smooth muscles leading to reduced blood flow. ( NCI )] (UMLS (NCI) C0016298) =Steroid; Pharmacologic Substance ;
=Pregnadienes;
Steroids, Fluorinated;
FLUOCINOLONE;
=(6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione;
FLUNISOLIDE;
FLUOCINOLONE ACETONIDE PWDR,TOP;
FLUOCINOLONE ACETONIDE 0.2 %;
FLUOCINOLONE ACETONIDE 0.01 %;
FLUOCINOLONE ACETONIDE 0.025 %;
FLUOCINOLONE ACETONIDE 0.1 %
133. (2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid, Ethyl Ester
[A synthetic oral retinoid that is a prodrug of acitretin. Etretinate activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells. Etretinate is no longer commercially available in the U.S. due to the extended potential for teratogenic effects related to its long half-life. (NCI04) ( NCI )] (UMLS (NCI) C0015137) =Organic Chemical; Pharmacologic Substance ;
=Retinoic Acid Agent;
[DE801] ANTIPSORIATICS, SYSTEMIC =ETRETINATE 10 MG;
ETRETINATE 25 MG;
183. (6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester
[The propionate salt form of fluticasone, a synthetic trifluorinated glucocorticoid receptor agonist with antiallergic, antiinflammatory and antipruritic effects. Binding and activation of the glucocorticoid receptor results in the activation of lipocortin that in turn inhibits cytosolic phospholipase A2, which triggers cascade of reactions involved in synthesis of inflammatory mediators, such as prostaglandins and leukotrienes. Secondly, mitogen-activated protein kinase (MAPK) phosphatase 1 is induced, thereby leads to dephosphorylation and inactivation of Jun N-terminal kinase directly inhibiting c-Jun mediated transcription. Finally, transcriptional activity of nuclear factor (NF)-kappa-B is blocked, thereby inhibits the transcription of cyclooxygenase 2, which is essential for prostaglandin production. ( NCI )] (UMLS (NCI) C0117996) =Organic Chemical; Pharmacologic Substance =FLUTICASONE;
=FLUTICASONE PROPIONATE 50 MCG;
FLUTICASONE PROPIONATE 500 MCG;
FLUTICASONE PROPIONATE 50 MCG/ACTUAT;
FLUTICASONE PROPIONATE 0.05 %;
FLUTICASONE PROPIONATE 110 MCG/ACTUAT;
FLUTICASONE PROPIONATE 44 MCG/ACTUAT;
FLUTICASONE PROPIONATE 220 MCG/ACTUAT;
FLUTICASONE PROPIONATE 250 MCG;
FLUTICASONE PROPIONATE 100 MCG;
FLUTICASONE PROPIONATE 0.005 %
134. (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
[A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. (NCI04) ( NCI )] (UMLS (NCI) C0077063) =Organic Chemical; Antibiotic ;
184. (6R)-DDATHF
[A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called antifolates. ( NCI )] (UMLS (NCI) C0048852) =Organic Chemical; Pharmacologic Substance ;
135. (2R,3R)-(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, 2,3-Dihydoxybutanedioate Monohydrate (1:1) (Salt)
[A bitartrate salt of norepinephrine, a synthetic phenylethylamine that mimics the sympathomimetic actions of the endogenous norepinephrine. Norepinephrine bitartrate acts directly on the alpha- and beta-adrenergic receptors. Clinically, norepinephrine is used as a peripheral vasoconstrictor that causes constriction of arterial and venous beds via its alpha-adrenergic action. It is also used as a potent inotropic and chronotropic stimulator of the heart mediated through its beta1 adrenergic action. ( NCI )] (UMLS (NCI) C0028333) =Organic Chemical; Pharmacologic Substance ;
=(.+-.)-Noradrenaline;
=NOREPINEPHRINE BITARTRATE 1 MG/ML;
185. (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate
[A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents. ( NCI )] (UMLS (NCI) C0065295) =Organic Chemical; Antibiotic ;
=[AM130] BETA-LACTAMS ANTIMICROBIALS, OTHER;
Unclassified Ingredients =LORACARBEF 100 MG/5ML;
LORACARBEF 200 MG;
LORACARBEF 200 MG/5ML;
LORACARBEF 400 MG
136. (2R,3R,4S)-4-(1,3-Benzodioxo-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid
[A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called endothelin-1 protein receptor antagonists. ( NCI )] (UMLS (NCI) C0935914) ATRASENTAN;
=Organic Chemical; Pharmacologic Substance ;
186. (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
[A carboline-based compound with vasodilatory properties. Tadalafil selectively inhibits the cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase- (PDE-5)-mediated degradation of cGMP, which is found in the smooth muscle of the corpus cavernosa and corpus spongiosum of the penis. Inhibition of cGMP degradation by tadalafil results in prolonged muscle relaxation, vasodilation, and blood engorgement of the corpus cavernosa, thereby prolonged penile erection. ( NCI )] (UMLS (NCI) C1176316) TADALAFIL;
TADALAFIL UNIDENTIFIED =Organic Chemical; Pharmacologic Substance
137. (2R,3S)-N-Hydroxy-N-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide
[An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Batimastat is a matrix metalloproteinase inhibitor. ( NCI )] (UMLS (NCI) C0215791) =Organic Chemical; Pharmacologic Substance ;
187. (6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid
[A beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. ( NCI )] (UMLS (NCI) C0007546) =Organic Chemical; Antibiotic =Cephalosporanic Acids;
[AM101] CEPHALOSPORINS, 1ST GENERATION =(6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Sodium Salt
138. (2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentad
[semi-synthetic macrolide antibiotic; related to erythromycin. ( CSP )] (UMLS (NCI) C0052796) =Organic Chemical; Antibiotic =macrolide antibiotic;
ERYTHROMYCIN;
[AM200] ERYTHROMYCINS/MACROLIDES;
=AZITHROMYCIN DIHYDRATE;
AZITHROMYCIN 100 MG/5ML;
AZITHROMYCIN 250 MG;
AZITHROMYCIN 200 MG/5ML;
AZITHROMYCIN 600 MG;
AZITHROMYCIN 500 MG;
188. (6R,7R)-7-(((2R)-Amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid
[A semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. ( NCI )] (UMLS (NCI) C0007538) =Organic Chemical; Antibiotic =cephalexin;
[AM101] CEPHALOSPORINS, 1ST GENERATION =CEFADROXIL MONOHYDRATE;
Cefadroxil 100 MG/ML;
CEFADROXIL 1 GM;
CEFADROXIL 125 MG/5ML;
CEFADROXIL 250 MG/5ML;
CEFADROXIL 500 MG;
139. (2R,3S,4S,5E,7S,8S,9R)-2,9- Dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene
[Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro. ( NCI )] (UMLS (NCI) C0113086) =Organic Chemical; Biologically Active Substance ;
189. (6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid
[A beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cephradine binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. ( NCI )] (UMLS (NCI) C0007738) =Organic Chemical; Antibiotic =cephalexin;
[AM101] CEPHALOSPORINS, 1ST GENERATION =CEPHRADINE 250 MG;
CEPHRADINE 500 MG;
CEPHRADINE 125 MG/5ML;
CEPHRADINE 250 MG/5ML
140. (2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester
[HMG coA reductase inhibitor which inhibits cholesterol biosynthesis and thus lowers blood cholesterol levels; also blocks isoprenylation of protein CAAX motifs. ( CSP )] (UMLS (NCI) C0024027) =Organic Chemical; Pharmacologic Substance ;
=antihypercholesterolemic agent;
[CV350] ANTILIPEMIC AGENTS;
naphthalene;
=[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate;
LOVASTATIN 10 MG;
LOVASTATIN 20 MG;
LOVASTATIN 40 MG;
190. (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid
[Semisynthetic wide-spectrum cephalosporin with prolonged action, probably due to beta-lactamase resistance. It is used also as the nafate. ( MSH )] (UMLS (NCI) C0007541) =Organic Chemical; Antibiotic =Cephalosporanic Acids;
[AM102] CEPHALOSPORINS, 2ND GENERATION =CEFOPERAZONE;
Cefamandole Nafate;
(6R-trans)-7-(((2-(Aminomethyl)phenyl)acetyl)amino)-3-(((1-(carboxymethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid;
Cefamandole Nafate;
141. (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid
[An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor. ( NCI )] (UMLS (NCI) C0338344) =Organic Chemical; Pharmacologic Substance
191. (6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,14,15,15a,16-Hexadecahydro-10,13-dimethylspiro-(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione
[A synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. Drospirenone binds to the progesterone receptor, the resulting complex becomes activated and binds to specific sites on DNA. This results in a suppression of LH activity and an inhibition of ovulation as well as an alteration in the cervical mucus and endometrium. This leads to an increased difficulty of sperm entry into the uterus and implantation. This drug is used in oral contraceptives. ( NCI )] (UMLS (NCI) C0043822) =Organic Chemical; Pharmacologic Substance ;
=[HS200] CONTRACEPTIVES, SYSTEMIC;
Unclassified Ingredients =DROSPIRENONE 3 MG
142. (2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-(+)-tartrate(1:1)
[A phenylalkylamine sympathomimetic amine with appetite depressant property. Phendimetrazine tartrate is a prodrug that is hydrolyzed to the active metabolite phenmetrazine, which competes with norepinephrine and dopamine for their presynaptic transporters, thereby blocks the reuptake of these monoamines at the neuronal junctions. As a result, this prolongs activities of dopamine and norepinephrine and leads to central nervous system (CNS) stimulation and metabolic effects, including appetite-suppression, decreased gastric acid secretion and increased blood pressure. ( NCI )] (UMLS (NCI) C0148932) =Organic Chemical; Pharmacologic Substance ;
=PHENDIMETRAZINE;
=PHENDIMETRAZINE TARTRATE 35 MG;
PHENDIMETRAZINE TARTRATE 105 MG;
PHENDIMETRAZINE TARTRATE 17.5 MG
192. (6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Sodium Salt
[The sodium salt form of cefazolin, a beta-lactam antibiotic and first-generation cephalosporin with bactericidal activity. Cefazolin binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis. ( NCI )] (UMLS (NCI) C0700526) =Organic Chemical; Antibiotic =(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid;
=CEFAZOLIN SODIUM 10 GM;
CEFAZOLIN SODIUM 10 MG/ML;
CEFAZOLIN SODIUM 20 GM/VIL;
CEFAZOLIN SODIUM 20 MG/ML;
CEFAZOLIN SODIUM 5 GM/VIL;
CEFAZOLIN SODIUM 1 GM;
CEFAZOLIN SODIUM 500 MG
143. (2S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside
[An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata. Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04) ( NCI )] (UMLS (NCI) C0007308) =Organic Chemical; Antibiotic ;
193. (6R-trans)-7-(((2-(Aminomethyl)phenyl)acetyl)amino)-3-(((1-(carboxymethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid
[A semi-synthetic, broad-spectrum, beta-lactam, second-generation cephalosporin antibiotic with bactericidal activity. Ceforanide causes inhibition of bacterial cell wall synthesis by inactivating penicillin binding proteins (PBPs) thereby interfering with the final transpeptidation step required for cross-linking of peptidoglycan units which are a component of the cell wall. This results in a reduction of cell wall stability and causes cell lysis. ( NCI )] (UMLS (NCI) C0055008) =Organic Chemical; Antibiotic ;
=(6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid;
[AM102] CEPHALOSPORINS, 2ND GENERATION;
TO BE DELETED INGREDIENT PREPARATIONS;
144. (2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid
[semi-synthetic derivative of penicillin that functions as an orally active broad-spectrum antibiotic. ( CSP )] (UMLS (NCI) C0002680) =Organic Chemical; Antibiotic ;
194. (7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione
[The dipropionate salt form of alclometasone, a synthetic corticosteroid with low to medium potency. Alclometasone dipropionate is a glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, immunosuppressive, antipruritic, and vasoconstrictive effects of natural glucocorticoids. This drug interacts with specific intracellular receptors and binds to DNA to modify gene expression. This results in an induction of synthesis of certain proteins while inhibiting the synthesis of others. Alclometasone dipropionate is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. (NCI05) ( NCI )] (UMLS (NCI) C0051113) =Steroid; Pharmacologic Substance ;
=(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione;
ALCLOMETASONE =ALCLOMETASONE DIPROPIONATE 0.05 %;
145. (2S-cis)-Benzoic Acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide
[A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin. Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39590&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1458" NCI Thesaurus) ( PDQ )] (UMLS (NCI) C0206788) =Organic Chemical; Antibiotic ;
195. (7aS-cis)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one
(UMLS (NCI) C0664750) =Organic Chemical; Pharmacologic Substance ;
146. (3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone
[A nonsteroidal selective estrogen receptor modulator (SERM) with potential antineoplastic activity. Trioxifene competes with estradiol in binding to estrogen receptor alpha (ER alpha), thereby inhibiting ER alpha-mediated signal transduction and gene expression. In addition, trioxifene exerts intrinsic estrogenic activity depending on the tissue. Clinical development of trioxifene has not been preceded due to its side effect profile and lack of increased efficacy over tamoxifen. ( NCI )] (UMLS (NCI) C0077238) =Organic Chemical; Pharmacologic Substance ;
196. (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione
[A 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. ( NCI )] (UMLS (NCI) C0014582) =Organic Chemical; Pharmacologic Substance =antineoplastic antibiotics;
(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione =(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
147. (3-beta)-cholest-5-en-3-ol 4-(bis(2-chloroethyl)amino)benzeneacetate
[A steroidal nitrogen mustard with antineoplastic and mutagenic activities. After attachment to cell-surface steroid receptors and uptake, phenesterin enters the nucleus where it alkylates macromolecules, resulting in decreased cell proliferation. (NCI04) ( NCI )] (UMLS (NCI) C0070556) =Organic Chemical; Pharmacologic Substance ;
197. (8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione Hydrochloride
[The hydrochloride salt of the 4'-epi-isomer of the anthracycline antineoplastic antibiotic doxorubicin. Epirubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. ( NCI )] (UMLS (NCI) C0700582) =Organic Chemical; Pharmacologic Substance =(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
=EPIRUBICIN HCL 2 MG/ML
148. (3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol Diacetate
[The diacetate salt form of ethynodiol, a semi-synthetic progestational hormone agonist. Ethynodiol diacetate binds to cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. In addition, ethynodiol diacetate has weak oestrogenic and androgenic properties. ( NCI )] (UMLS (NCI) C0015117) =Steroid; Pharmacologic Substance ;
=Norpregnenes;
ETHYNODIOL =ETHYNODIOL DIACETATE 1 MG
198. (8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione
[antineoplastic antibiotic obtained from Streptomyces peucetius; a hydroxy derivative of daunorubicin. ( CSP )] (UMLS (NCI) C0013089) =Organic Chemical; Antibiotic ;
=Anthracycline Antibiotic;
antineoplastic antibiotics;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione;
=(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;
N-trifluoroacetyladriamycin 14-valerate;
14-Hydroxydaunorubicin Hydrochloride;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride;
14-Hydroxydaunorubicin Hydrochloride;
(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride;
149. (3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid
[A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder. Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries. This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol. Ursodiol also reduces the absorption of cholesterol from the intestinal tract. ( NCI )] (UMLS (NCI) C0042105) =Steroid; Pharmacologic Substance; Biologically Active Substance =Deoxycholic Acid;
(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid;
[GA900] GASTRIC MEDICATIONS, OTHER;
=(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid;
URSODIOL 250 MG;
Ursodeoxycholate 300 MG
199. (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride
[A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin. Doxorubicin intercalates between base pairs in the DNA helix, thereby preventing DNA replication and ultimately inhibiting protein synthesis. Additionally, doxorubicin inhibits topoisomerase II which results in an increased and stabilized cleavable enzyme-DNA linked complex during DNA replication and subsequently prevents the ligation of the nucleotide strand after double-strand breakage. Doxorubicin also forms oxygen free radicals resulting in cytotoxicity secondary to lipid peroxidation of cell membrane lipids. Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects; a liposomal formulation of doxorubicin also modulates toxicity, specifically the cardiac effects commonly seen with anthracycline antitumor drugs. ( NCI )] (UMLS (NCI) C1445757) Doxorubicin HCl Liposome;
Doxorubicin Hydrochloride Liposomal;
Doxorubicin Hydrochloride Liposome;
DOXORUBICIN HYDROCHLORIDE LIPOSOME PREPARATION;
Liposomal Doxorubicin Hydrochloride;
=Organic Chemical; Antibiotic =(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione;
=DOXORUBICIN HYDROCHLORIDE LIPOSOME 2 MG/ML;
150. (3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid
[A pentacyclic lupane-type triterpene derivative of betulin (isolated from the bark of Betula alba, the common white birch) with antiinflammatory, anti-HIV and antineoplastic activities. Betulinic acid induces apoptosis through induction of changes in mitochondrial membrane potential, production of reactive oxygen species, and opening of mitochondrial permeability transition pores, resulting in the release of mitochondrial apogenic factors, activation of caspases, and DNA fragmentation. Although originally thought to exhibit specific cytotoxicity against melanoma cells, this agent has been found to be cytotoxic against non-melanoma tumor cell types including neuroectodermal.and brain tumor cells. ( NCI )] (UMLS (NCI) C0053530) =Organic Chemical; Pharmacologic Substance ;
200. (8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione
[anthracycline antibiotic produced by Streptomyces coeruleorubidus or Streptomyces peucetius and used as an antineoplastic. ( CSP )] (UMLS (NCI) C0011015) =Organic Chemical; Pharmacologic Substance =Anthracycline Antibiotic;
antineoplastic antibiotics;
Anthracyclines;
=(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione;
(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside;
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride;
DAUNORUBICIN CITRATE LIPOSOME;
5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride;
DAUNORUBICIN CITRATE LIPOSOME

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