- 201. (99m)Tc-Medronate
- [A radiopharmaceutical containing methylene diphosphonate (medronate; MDP) complexed with the gamma-emitting radionuclide technetium Tc 99m with potential bone imaging activity. Upon intravenous administration, skeletal uptake of Tc 99m MDP occurs as a function of skeletal blood flow and is related to osteogenic activity. The medronate moiety of this agent has affinity for hydroxyapatite crystals in bone with abnormal accumulation at sites with increased osteoid mineralization. Labeling with Tc 99m allows localization and visualization of areas in which skeletal uptake of Tc 99m is impaired, such as in areas of abnormal osteogenesis. ( NCI )] (UMLS (NCI) C0039416) =Organophosphorus Compound; Indicator, Reagent, or Diagnostic Aid
| - 251. (R)-4-(3,4-Dihydro-8,8-dimethyl-2H,8H-benzo(1,2-b:3,4-b')dipyran-3-yl)-1,3-benzenediol
- (UMLS (NCI) C0664589) =Organic Chemical; Pharmacologic Substance ;
|
- 202. (99m)Tc-P280
- [A radioconjugate comprised of the small peptide apcitide labeled with the gamma-emitting technetium TC99m (metastable Tc-99). Apcitide binds to platelet glycoprotein (GP) GPIIb/IIIa receptors on the surface of activated platelets. Labeling apcitide with TC99m allows localization of thrombus formation by gamma-ray imaging equipment and the ability to distinguish between old, inactive thrombi and new, active thrombi. ( NCI )] (UMLS (NCI) C0766234) A9504;
Technetium Tc-99m Apcitide;
=Amino Acid, Peptide, or Protein; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid | - 252. (R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide
- [A sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably by slowing the formation of bicarbonate ions, and results in a reduction in intraocular pressure. Brindazolamide is used to treat increased pressure in the eye caused by open-angle glaucoma. ( NCI )] (UMLS (NCI) C0673966) =Organic Chemical; Pharmacologic Substance =azopt;
[OP104] CARBONIC ANHYDRASE INHIBITORS, SYSTEMIC OPHTHALMIC =BRINZOLAMIDE 1 %;
|
- 203. (9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
- [exhibits cytotoxic or antitumor properties; naturally derived from cultures of Streptomyces; inhibits protein kinase C. ( CSP )] (UMLS (NCI) C0075193) =Organic Chemical; Pharmacologic Substance ;
=alkaloid;
| - 253. (R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one
- [An anticancer drug that belongs to the family of drugs called alkylating agents. Also called irofulven. ( NCI )] (UMLS (NCI) C0532362) =Organic Chemical; Pharmacologic Substance
|
- 204. (9beta,10alpha)-17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
- [The acetate salt form of megestrol, a synthetic derivative of the naturally occurring female sex hormone progesterone with potential anti-estrogenic and antineoplastic activity. Mimicking the action of progesterone, megestrol acetate binds to and activates nuclear progesterone receptors in the reproductive system, and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. This leads to an alteration in protein synthesis, which modulates cell growth of reproductive tissues. Due to the negative feedback mechanism seen with progesterone, megestrol also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impedes the growth of estrogen-sensitive tumor cells. ( NCI )] (UMLS (NCI) C0065879) =Steroid; Pharmacologic Substance; Hormone =MEG;
=Megestrol 20 MG;
MEGESTROL ACETATE 200 MG/5ML;
MEGESTROL ACETATE 40 MG;
| - 254. (R)-N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine
- [A white, crystalline powder that is very unstable in the presence of light but fairly heat resistant. Ochratoxin A is a widespread, naturally occurring mycotoxin that is produced by some fungi, especially by Aspergillus and Penicillium, and is a very common food contaminant found on grains, coffee beans, nuts, decaying vegetation, moldy cereals and animal feeds. This toxin is used in research as an experimental teratogen and carcinogen. Ochratoxin A is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing urinary tract tumors. (NCI05) ( NCI )] (UMLS (NCI) C0069299) =Organic Chemical; Pharmacologic Substance ;
|
- 205. (9E)-Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime]
- [Semisynthetic derivative of erythromycin. It is concentrated by human phagocytes and is bioactive intracellularly. While the drug is active against a wide spectrum of pathogens, it is particularly effective in the treatment of respiratory and genital tract infections. ( MSH )] (UMLS (NCI) C0035891) =Organic Chemical; Antibiotic ;
| - 255. (R,S)-N-[3-[(4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino] propyl]tetrahydro-2-furancarboxamide Hydrochloride
- [The hydrochloride salt of alfuzosin, a quinazoline compound with smooth muscle-relaxing activity. Alfuzosin selectively binds to and antagonizes post-synaptic alpha-1-adrenoreceptors in smooth muscle of the prostate, bladder base, bladder neck, prostatic capsule, and prostatic urethra, initiating relaxation of smooth muscle and resulting in improvement of urine flow and the symptoms of benign prostatic hyperplasia (BPH). This agent also blocks alpha-1-adrenoreceptors in peripheral vascular smooth muscle, resulting in vasodilatation and a decrease in peripheral vascular resistance. ( NCI )] (UMLS (NCI) C0102130) =Organic Chemical; Pharmacologic Substance ;
|
- 206. (9S)-6'-Methoxycinchonan-9-ol Sulfate (2:1) (salt)
- [The sulfate salt form of quinidine, an alkaloid with antimalarial and antiarrhythmic (Class la) properties. Quinidine sulfate exerts its anti-malarial activity by acting primarily as an intra-erythrocytic schizonticide through association with the hemepolymer (hemozoin) in the acidic food vacuole of the parasite thereby preventing further polymerization by heme polymerase enzyme. This results in accumulation of toxic heme and death of the parasite. Quinidine sulfate exerts its antiarrhythmic effects by depressing the flow of sodium ions into cells during phase 0 of the cardiac action potential, thereby slowing the impulse conduction through the atrioventricular (AV) node, reducing the rate of phase 0 depolarization and prolonging the refractory period. Quinidine sulfate also reduces the slope of phase 4 depolarization in Purkinje-fibres resulting in slowed conduction and reduced automaticity in the heart. ( NCI )] (UMLS (NCI) C0034415) =Organic Chemical; Pharmacologic Substance ;
=QUINIDINE;
9S-6'-Methoxy-cinchonan-9-ol, Mono-D-gluconate(salt);
quinidine polygalacturonate;
=QUINIDINE SULFATE 200 MG;
QUINIDINE SULFATE 100 MG;
QUINIDINE SULFATE 300 MG | - 256. (RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ butyraldehyde
- [A steroid being studied as an anticancer drug. Budesonide is commonly used to treat asthma and rhinitis. ( NCI )] (UMLS (NCI) C0054201) =Steroid; Pharmacologic Substance =Pregnenediones;
[NT200] ANTI-INFLAMMATORIES, NASAL;
[RE101] ANTI-INFLAMMATORIES, INHALATION;
=Budesonide 0.2 MG/ACTUAT;
BUDESONIDE 3 MG;
BUDESONIDE 0.25 MG/ML;
Budesonide 0.32 MG/ACTUAT;
|
- 207. (aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one
- [11-((4-dimethylamino) phenyl)-17-hydroxy-17-(1-propynyl) estra-4,9- dien-3-one; progesterone and glucocorticoid antagonist with potential applications in terminating pregnancy, controlling menstruation, and treating hypercortisolism. ( CSP )] (UMLS (NCI) C0026088) =Steroid; Pharmacologic Substance ;
=abortifacient;
Estrenes;
hormone antagonist;
[HS200] CONTRACEPTIVES, SYSTEMIC =MIFEPRISTONE 200 MG;
| - 257. (S)-(-)-Perillyl alcohol
- [A drug used in cancer prevention that belongs to the family of plant drugs called monoterpenes. ( NCI )] (UMLS (NCI) C0207661) =Organic Chemical; Pharmacologic Substance; Biologically Active Substance
|
- 208. (All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid
- [A naturally-occurring acid of retinol. Tretinoin binds to and activates retinoic acid receptors (RARs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of tumorigenesis. This agent also inhibits telomerase, resulting in telomere shortening and eventual apoptosis of some tumor cell types. The oral form of tretinoin has teratogenic and embryotoxic properties. ( NCI )] (UMLS (NCI) C0040845) =Organic Chemical; Pharmacologic Substance =[AN000] ANTINEOPLASTICS;
[VT050] VITAMIN A;
[DE752] ANTIACNE AGENTS, TOPICAL;
=3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid;
TRETINOIN 10 MG;
TRETINOIN PWDR;
TRETINOIN 0.05 %;
TRETINOIN 0.1 %;
TRETINOIN 0.01 %;
TRETINOIN 0.025 %;
TRETINOIN 0.04 %;
| - 258. (S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline
- [potent and specific inhibitor of peptidyl dipeptidase A; it acts to suppress the renin-angiotensin system and inhibits blood pressure responses to exogenous angiotensin. ( CSP )] (UMLS (NCI) C0006938) =Amino Acid, Peptide, or Protein; Pharmacologic Substance =Amino Acids, Cyclic;
[CV800] ACE INHIBITORS;
PROLINE;
=CAPTOPRIL 100 MG;
CAPTOPRIL 12.5 MG;
CAPTOPRIL 25 MG;
CAPTOPRIL 50 MG;
|
- 209. (All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid
- [A drug used in cancer prevention that belongs to the family of drugs called retinoids. It is also used in the treatment of psoriasis. ( NCI )] (UMLS (NCI) C0050559) =Organic Chemical; Pharmacologic Substance ;
=Retinoic Acid Agent;
[DE801] ANTIPSORIATICS, SYSTEMIC =ACITRETIN 10 MG;
ACITRETIN 25 MG | - 259. (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol
- [A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis. ( NCI )] (UMLS (NCI) C0040233) =Organic Chemical; Pharmacologic Substance =Propanolamines;
[CV100] BETA-BLOCKERS/RELATED;
[OP101] BETA-BLOCKERS, TOPICAL OPHTHALMIC;
[OP109] ANTIGLAUCOMA, OTHER =TIMOLOL MALEATE;
TIMOLOL HEMIHYDRATE;
TIMOLOL MALEATE;
TIMOLOL HEMIHYDRATE;
|
- 210. (all-Z)-5,8,11,14-Eicosatetraenoic Acid
- [An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.(ChemID Plus) ( NCI )] (UMLS (NCI) C0003695) =Eicosanoid ;
| - 260. (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
- [antineoplastic drug which acts as a DNA topoisomerase inhibitor. ( CSP )] (UMLS (NCI) C0146224) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
(+)-Camptothecin =(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride |
- 211. (Aorto)coronary bypass of four or more coronary arteries
- [ ] (UMLS (ICD9CM) C0190236) =Therapeutic or Preventive Procedure
| - 261. (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'
6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride - [An oral formulation of hydrochloride salt of topotecan, a semisynthetic derivative of camptothecin, a quinoline alkaloid extracted from the Asian tree Camptotheca acuminate, with potential antineoplastic activity. Topotecan selectively inhibits topoisomerase I activity by stabilizing the topoisomerase I-DNA covalent complexes during S phase of cell cycle, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Compared to intravenously administered topotecan, the oral formulation is a more convenient way of administering this agent. ( NCI )] (UMLS (NCI) C0886549) Hycamptamine;
Oral Topotecan Hydrochloride;
Topotecan HCl;
Topotecan hydrochloride;
topotecan hydrochloride (oral);
TOPOTECAN HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance ;
=(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione;
=TOPOTECAN HYDROCHLORIDE 4 MG |
- 212. (Aorto)coronary bypass of one coronary artery
- [ ] (UMLS (ICD9CM) C0190224) =Therapeutic or Preventive Procedure
| - 262. (S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole
- [oral imidazole used as an anthelminthic, effective against roundworms, hookworms and strongyloids; also an immunopotentiator; has been used to stimulate immune response in cancer. ( CSP )] (UMLS (NCI) C0023556) =Organic Chemical; Pharmacologic Substance =Anthelminthics;
imidazole;
thiazole;
[AN400] ANTINEOPLASTIC ADJUVANTS =LEVAMISOLE 50 MG |
- 213. (Aorto)coronary bypass of three coronary arteries
- [ ] (UMLS (ICD9CM) C0190232) =Therapeutic or Preventive Procedure
| - 263. (S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole Monohydrochloride
- [The chloride salt form of the anthelmintic drug levamisole. Co-administered with fluorouracil in the treatment of Dukes' stage C colon cancer, levamisole restores immune function through stimulating antibody formation, enhancing T-cell activity, and potentiating macrophage function. (NCI04) ( NCI )] (UMLS (NCI) C0733383) Cloridrato de Levamizol;
LEVAMISOLE HYDROCHLORIDE;
l-Tetramisole Hydrochloride;
=Organic Chemical; Pharmacologic Substance |
- 214. (Aorto)coronary bypass of two coronary arteries
- [ ] (UMLS (ICD9CM) C0190228) =Therapeutic or Preventive Procedure
| - 264. (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide
- [A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity. ( NCI )] (UMLS (NCI) C0377265) =Organic Chemical; Pharmacologic Substance ;
=[CN400] ANTICONVULSANTS;
etiracetam =LEVETIRACETAM 500 MG;
LEVETIRACETAM 250 MG;
LEVETIRACETAM 750 MG;
|
- 215. (asterisk) Life of the "unit." Used for blood products.
- (UMLS (HL7) C1547057) =Temporal Concept =Duration categories;
| - 265. (S)-alpha-Methylbenzeneethanamine Sulfate
- [The salt of the dextro-isomer of amphetamine and sympathomimetic amine with CNS stimulating properties. Dextroamphetamine sulphate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of narcolepsy and attention deficit hyperactivity disorder. ( NCI )] (UMLS (NCI) C0011810) =Organic Chemical; Pharmacologic Substance ;
=Dextroamphetamine;
=DEXTROAMPHETAMINE SULFATE 1.25 MG;
DEXTROAMPHETAMINE SULFATE 15 MG;
DEXTROAMPHETAMINE SULFATE 5 MG;
DEXTROAMPHETAMINE SULFATE 5 MG/5ML;
DEXTROAMPHETAMINE SULFATE 7.5 MG;
DEXTROAMPHETAMINE SULFATE 10 MG;
DEXTROAMPHETAMINE SULFATE 2.5 MG;
DEXTROAMPHETAMINE SULFATE 3.75 MG;
|
- 216. (betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid
- [a synthetic lipid-lowering agent; an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase that catalyzes the conversion of HMG-CoA to mevalonate, an early and rate-limiting step in cholesterol biosynthesis. ( CSP )] (UMLS (NCI) C0286651) =Organic Chemical; Pharmacologic Substance =antihypercholesterolemic agent;
[CV350] ANTILIPEMIC AGENTS;
Heptanoic Acids;
pyrrole =Atorvastatin Calcium | - 266. (S)-dihydroorotate:oxygen oxidoreductase
- [A flavoprotein (FAD, FMN). Catalyzes the reaction of S-dihydroorotate and oxygen into orotate and hydrogen peroxide. Ferricyanide can act as acceptor. [EC 1.3.3.1 created 1961] (from IUBMB) ( NCI )] (UMLS (NCI) C0058099) =Amino Acid, Peptide, or Protein; Enzyme ;
|
- 217. (CH3)2CHCH2CH3
- [An organic, branched-chain alkane with five carbon atoms. ( NCI )] (UMLS (NCI) C0083072) =Organic Chemical
| - 267. (S)-N,N'-bis(2-Hydroxy-1-(hydroxymethyl)ethyl)-2,4,6-triiodo-5-lactamidoisophthalamide
- [An organic iodine compound and used as a non-ionic water soluble radiographic contrast medium. Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05) ( NCI )] (UMLS (NCI) C0022026) =Organic Chemical; Indicator, Reagent, or Diagnostic Aid =Triiodobenzoic Acids;
[DX101] NON-IONIC CONTRAST MEDIA =IOPAMIDOL 410 MG/ML;
IOPAMIDOL 510 MG/ML;
IOPAMIDOL 261 MG/ML;
IOPAMIDOL 612 MG/ML;
IOPAMIDOL 755 MG/ML;
IOPAMIDOL 408 MG/ML;
|
- 218. (Dichloromethylene)bisphosphonic Acid
- [A first-generation bisphosphonate with anti-resorptive and anti-hypercalcemic activity. Clodronic acid adsorbs onto the surface of the hydroxyapatite crystals in bone matrix. Although the exact mechanism through which clodronic acid exerts its cytotoxic effect on osteoclasts has yet to be fully elucidated, this agent is metabolized intracellularly to a toxic beta-gamma-methylene analog of adenosine triphosphate (ATP), AppCCl2p. The ATP analog AppCCl2p competitively inhibits ADP/ATP translocase, thereby interfering with mitochondrial membrane potential and cellular energy metabolism. This may cause osteoclast apoptosis and, eventually, inhibiting osteoclast-mediated bone resorption. ( NCI )] (UMLS (NCI) C0012081) =Organophosphorus Compound; Pharmacologic Substance
| - 268. (S)-N,N,alpha-Trimethylphenethylamine
- (UMLS (NCI) C0058252) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance
|
- 219. (Diethylenetriamine)pentaacetic acid
- [An edetate and a chelating agent used in preparing radiopharmaceuticals. Pentetic acid (DTPA) has strong affinity for iron but also shows affinities for other heavy metals, thereby is used in the treatment of iron-storage disease and poisoning from heavy and radioactive metals. DTPA may chelate metallic moieties of unbound, extracellular radioimmunotherapeutics, thereby aggregating radioimmunotherapeutics locally to higher concentrations, and improving tumor cell radiocytotoxicity, while sparing normal tissues from the radiocytotoxic effects. In addition, DTPA is used in radioimaing procedures when complexes with radioisotopes, ex., Tc 99m or In 111. ( NCI )] (UMLS (NCI) C0013254) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid =Acetic Acids;
Polyamines;
[DX201] IMAGING AGENTS (IN VIVO) RADIOPHARMACEUTICALS;
Inactive Ingredient Preparations =Gadolinium DTPA;
DIETHYLENETRIAMINE PENTAACETIC ACID 0.15 MG/ML;
PENTETIC ACID 10 MG;
| - 269. (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide
- [inhibits tubulin-tubulin binding and thus destabilizes microtubules; used to block mitosis, axonal transport, and other microtubule dependent cellular functions in vitro, and clinically to treat gout. ( CSP )] (UMLS (NCI) C0009262) =Organic Chemical; Pharmacologic Substance ;
=alkaloid;
Antimitotic Agent;
[MS400] ANTIGOUT AGENTS;
cycloheptane =COLCHICINE 0.5 MG;
COLCHICINE 0.5 MG/ML;
COLCHICINE 0.6 MG;
COLCHICINE 0.65 MG |
- 220. (DMSO)
- [highly polar organic liquid, that is used widely as a chemical solvent; because of its ability to penetrate biological membranes, it is used as a vehicle for topical application of pharmaceuticals; it is also used to protect tissue during cryopreservation; dimethyl sulfoxide shows a range of pharmacological activity including analgesia and anti-inflammation. ( CSP )] (UMLS (NCI) C0012403) =Organic Chemical; Pharmacologic Substance ;
=Sulfoxides;
sulfoxide;
Inactive Ingredient Preparations;
=DIMETHYL SULFOXIDE 50 %;
DIMETHYL SULFOXIDE 100 %;
| - 270. (S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide
- [A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus. Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA. This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04) ( NCI )] (UMLS (NCI) C0135981) =Amino Acid, Peptide, or Protein; Antibiotic ;
|
- 221. (E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid
- [specific isomer of hexahydro-5-hydroxy-4- (3-hydroxy-4-methyl-1- octen-6-ynyl) pentalenevaleric acid; prostacyclin analog and agonist; has vasodilator and anticoagulant actions and therefore may be useful for treating a variety of vascular disorders. ( CSP )] (UMLS (NCI) C0079594) =Eicosanoid; Pharmacologic Substance =prostaglandin analog;
| - 271. (S)-Pyrrolidinecarbodithioic Acid
- (UMLS (NCI) C0084183) =Organic Chemical; Pharmacologic Substance
|
- 222. (E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene
- [A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM). Droloxifene competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. (NCI) ( NCI )] (UMLS (NCI) C0047498) =Organic Chemical; Pharmacologic Substance ;
| - 272. (S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called alkylating agents. ( NCI )] (UMLS (NCI) C0076959) =Organic Chemical; Pharmacologic Substance ;
|
- 223. (E)-2-Butenedioic Acid
- (UMLS (NCI) C0060825) =Organic Chemical; Pharmacologic Substance ;
=fumarate;
Inactive Ingredient Preparations =AL OH 400MG/MG OH 400MG/SIMETHICONE 30MG TAB,CHEWABLE;
| - 273. (SP-4-2)-Diamminedichloroplatinum
- [inorganic, water soluble platinum complex; radiation sensitizing agent. ( CSP )] (UMLS (NCI) C0008838) =Pharmacologic Substance; Inorganic Chemical =[AN000] ANTINEOPLASTICS;
(SP-4-2)-Diamminedichloroplatinum;
Nitrogen Compounds;
Platinum Agents;
Chlorine Compounds;
=(SP-4-2)-Diamminedichloroplatinum;
(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum;
CISPLATIN 0.5 MG/ML;
CISPLATIN 10 MG;
CISPLATIN 100 MG;
CISPLATIN 50 MG |
- 224. (E)-2-Butenedioic Acid, Dimethyl Ester
- (UMLS (NCI) C0058218) =Organic Chemical; Pharmacologic Substance ;
| - 274. (SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum
- [organoplatinum compound with antineoplastic activity. ( CSP )] (UMLS (NCI) C0079083) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
(SP-4-2)-Diamminedichloroplatinum;
Organoplatinum Compounds;
=CARBOPLATIN 450 MG;
CARBOPLATIN 150 MG;
CARBOPLATIN 50 MG;
|
- 225. (E)-2-Butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic Acid, Monomethanesulfonate
- [The mesylate salt form of eprosartan, a non-biphenyl, non-tetrazole, nonpeptide angiotensin II antagonist with antihypertensive activity. Eprosartan mesylate antagonizes angiotensin II type I receptors in tissues such as vascular smooth muscle and the adrenal gland. This prevents angiotensin II-induced vasoconstriction and prevents angiotensin II-mediated stimulation of aldosterone secretion by the adrenal cortex, which decreases the excretion of sodium and water and increases the excretion of potassium. ( NCI )] (UMLS (NCI) C0772203) 2-Thiophenepropanoic Acid, alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1H-imidazol-5-yl)methylene)-,(E)-, Monomethanesulfonate;
Eprosartan Mesylate;
EPROSARTAN MESYLATE PREPARATION =Organic Chemical; Pharmacologic Substance =Eprosartan;
=EPROSARTAN MESYLATE 400 MG;
EPROSARTAN MESYLATE 600 MG | - 275. (Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole Mononitrate
- [The nitrate salt form of oxiconazole, a synthetic imidazole derivative with an antifungal activity. Oxiconazole nitrate inhibits cytochrome P-450 dependent C-14 alpha demethylation of fungal sterols, which results in accumulation of 14 alpha-methyl sterols, inhibition of ergosterol synthesis, disruption of cell membrane permeability, and ultimately inhibition of cell wall synthesis. ( NCI )] (UMLS (NCI) C0142160) =Organic Chemical; Pharmacologic Substance
|
- 226. (E)-3,7-Dimethyl-2,6-octadien-1-ol
- (UMLS (NCI) C0061223) =Organic Chemical; Pharmacologic Substance ;
| - 276. (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate
- [The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, thereby inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma as well as in other cancers that express high levels of protein kinase C. ( NCI )] (UMLS (NCI) C0079589) =Organic Chemical; Pharmacologic Substance =1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene;
=TAMOXIFEN CITRATE 10 MG;
TAMOXIFEN CITRATE 20 MG |
- 227. (E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol
- [synthetic nonsteroidal estrogen used in the treatment of menopausal, postmenopausal, and other disorders sensitive to estrogens; an epigenetic carcinogen. ( CSP )] (UMLS (NCI) C0012203) =Organic Chemical; Pharmacologic Substance; Hazardous or Poisonous Substance =female antifertility drug;
[HS300] ESTROGENS;
estrogen analog;
stilbene;
Teratogen;
=(E)-4,4'-(1,2-ethenediyl)-bisphenol bis(dihydrogen phosphate);
DIETHYLSTILBESTROL 1 MG;
DIETHYLSTILBESTROL 5 MG;
| - 277. (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine
- [An anticancer drug that belongs to the family of drugs called antiestrogens. Toremifene blocks the effect of the hormone estrogen in the body. It may help control some cancers from growing, and it may delay or reduce the risk of cancer recurrence. ( NCI )] (UMLS (NCI) C0076836) =Organic Chemical; Pharmacologic Substance ;
=1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene;
[AN500] ANTINEOPLASTIC HORMONES =(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1) |
- 228. (E)-4,4'-(1,2-ethenediyl)-bisphenol bis(dihydrogen phosphate)
- [A synthetic nonsteroidal estrogen that competes with androgen receptors and prevents further growth of androgen dependent tumor cells. (NCI) ( NCI )] (UMLS (NCI) C0060692) =Organic Chemical; Pharmacologic Substance; Hormone =(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol;
TO BE DELETED INGREDIENT PREPARATIONS =DIETHYLSTILBESTROL DIPHOSPHATE 50 MG/ML;
DIETHYLSTILBESTROL DIPHOSPHATE 50 MG | - 278. (Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)
- [The citrate salt of a nonsteroidal triphenylethylene antiestrogen. Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM). This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity. Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. (NCI04) ( NCI )] (UMLS (NCI) C0117339) =Organic Chemical; Pharmacologic Substance ;
=(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine;
=TOREMIFENE CITRATE 60 MG;
|
- 229. (E)-4-[2-[4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl]phenoxy]ethyl]morpholine
- (UMLS (NCI) C0247161) =Organic Chemical; Pharmacologic Substance ;
| - 279. (Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
- [A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer. ( NCI )] (UMLS (NCI) C0038792) =Organic Chemical; Pharmacologic Substance =Indenes;
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC =SULINDAC 150 MG;
SULINDAC 200 MG;
|
- 230. (E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol
- [A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05) ( NCI )] (UMLS (NCI) C0073096) =Organic Chemical; Pharmacologic Substance ;
| - 280. (Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid
- [A drug that is being studied in the treatment and prevention of cancer. It has been shown to cause apoptosis (cell death) in cancerous and precancerous cells by acting through a group of cellular enzymes called cGMP phosphodiesterases. ( NCI )] (UMLS (NCI) C0075616) =Organic Chemical; Pharmacologic Substance
|
- 231. (E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic Acid
- [A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05) ( NCI )] (UMLS (NCI) C0054340) =Organic Chemical; Pharmacologic Substance ;
=TRIPROLIDINE;
[AH400] ANTIHISTAMINES, ALKYLAMINE =ACRIVASTINE 8 MG | - 281. (Z,Z)-9,12-Octadecadienoic Acid
- [A polyunsaturated essential fatty acid found mostly in plant oils. It is used in the biosynthesis of prostaglandins and cell membranes. ( NCI )] (UMLS (NCI) C0023749) =Lipid; Pharmacologic Substance; Biologically Active Substance =Linoleic Acids;
Inactive Ingredient Preparations =Lecithin 420 MG Oral Capsule |
- 232. (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene Methanamine
- [A synthetic allylamine derivative with antifungal activity. Terbinafine exerts its effect through inhibition of squalene epoxidase, thereby blocking the biosynthesis of ergosterol, an important component of fungal cell membranes. As a result, this agent disrupts fungal cell membrane synthesis and inhibits fungal growth. ( NCI )] (UMLS (NCI) C0076110) =Organic Chemical; Pharmacologic Substance =[AM700] ANTIFUNGALS;
naphthalene;
[DE102] ANTIFUNGAL, TOPICAL;
=(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine Hydrochloride | - 282. *Activity
- (UMLS (HL7) C1561536) =Idea or Concept =Kind of quantity;
|
- 233. (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine Hydrochloride
- [A synthetic allylamine derivative structurally related to naftifine, antifungal Terbinafine Hydrochloride blocks ergosterol biosynthesis by inhibition of squalene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane. Highly lipophilic, it tends to accumulate in skin, nails, and fatty tissues. Terbinafine is active against dermatophytes. (NCI04) ( NCI )] (UMLS (NCI) C0771029) Terbinafine Hydrochloride;
TERBINAFINE HYDROCHLORIDE PREPARATION =Organic Chemical; Pharmacologic Substance =(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene Methanamine;
=TERBINAFINE HYDROCHLORIDE 1 %;
TERBINAFINE HYDROCHLORIDE 250 MG | - 283. *Arbitrary
- (UMLS (HL7) C1264693) =Quantitative Concept =Kind of quantity;
|
- 234. (E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochloride
- [The hydrochloride salt form of naftifine, an allylamine derivate with synthetic broad-spectrum antifungal activity. Although the exact mechanism through which naftifine hydrochloride exerts its effect is unknown, it appears to selectively inhibit the enzyme squalene 2,3-epoxidase, thereby inhibiting the biosynthesis of sterol. This results in a decreased amount of sterols, especially ergosterol which is the primary fungal membrane sterol, and a corresponding accumulation of squalene in fungal cells. Naftifine hydrochloride can be fungicidal as well as fungistatic to yeasts depending on the concentration and the organisms involved. ( NCI )] (UMLS (NCI) C0304594) =Organic Chemical; Pharmacologic Substance =naftifin;
=NAFTIFINE HYDROCHLORIDE 1 % | - 284. *Catalytic Activity
- (UMLS (HL7) C1547012) =Quantitative Concept =Kind of quantity;
|
- 235. (E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
- [N-(4-hydroxy-3-methoxyphenylmethyl) -8-methyl-6-nonenamide; chili pepper extract and neuropeptide releasing agent selective for primary sensory peripheral neurons, used to experimentally manipulate substance P and other tachykinins, and as an analgesic for Herpes zoster infection. ( CSP )] (UMLS (NCI) C0006931) =Lipid; Pharmacologic Substance =Fatty Acids, Monounsaturated;
Solanaceous Alkaloids;
neuropharmacologic agent;
phenylamide;
[DE650] ANALGESICS, TOPICAL;
=CAPSAICIN 0.075 %;
CAPSAICIN 0.025 %;
CAPSAICIN 0.75 %;
CAPSAICIN 0.25 %;
| - 285. *Catalytic Concentration
- (UMLS (HL7) C1264648) =Quantitative Concept =Kind of quantity;
|
- 236. (E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione
- [A yellow pigment of the spice turmeric that is being studied in cancer prevention. ( NCI )] (UMLS (NCI) C0010467) =Organic Chemical; Pharmacologic Substance; Indicator, Reagent, or Diagnostic Aid
| - 286. *Catalytic Content
- (UMLS (HL7) C1264656) =Quantitative Concept =Kind of quantity;
|
- 237. (E,E)-3,7,11-Trimethyl-2,6,10-dodecatrien-1-ol
- [A colorless liquid extracted from oils of plants such as citronella, neroli, cyclamen, and tuberose. It is an intermediate step in the biological synthesis of cholesterol from mevalonic acid in vertebrates. It has a delicate odor and is used in perfumery. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed) ( MSH )] (UMLS (NCI) C0015637) =Lipid; Pharmacologic Substance
| - 287. *Catalytic Fraction
- (UMLS (HL7) C1305363) =Functional Concept; ;
=Kind of quantity;
|
- 238. (gamma)
- [The gamma-distribution used for data that is skewed and bounded to the right, i.e. where the maximum of the distribution curve is located near the origin. The g-distribution has a two parameters a and b. The relationship to mean m and variance s2 is m = a b and s2 = a b2. ( HL7V3.0 )] (UMLS (HL7) C1552644) =Intellectual Product =ProbabilityDistributionType;
| - 288. *Catalytic Rate
- (UMLS (HL7) C1264668) =Quantitative Concept =Kind of quantity;
|
- 239. (Glycolato-O,O')diammineplatinum(II)
- [A second-generation cisplatin analogue with antineoplastic activity. Containing a novel ring structure in which glycolate is bound to the platinum by a bidentate ligand, nedaplatin forms reactive platinum complexes that bind to nucelophillic groups in DNA, resulting in intrastrand and interstrand DNA cross-links, apoptosis and cell death. This agent appears to be less nephrotoxic and neurotoxic compared to both cisplatin and carboplatin. ( NCI )] (UMLS (NCI) C0093999) =Organic Chemical; Pharmacologic Substance
| - 289. *Coefficient
- [A constant number that serves as a measure of some property or characteristic. ( NCI )] (UMLS (HL7) C1707429) Coefficient =Quantitative Concept ;
=Kind of quantity;
|
- 240. (Laparoscopic) adjustment of size of adjustable gastric restrictive device
- [ ] (UMLS (ICD9CM) C1456111) ADJUST GAST RESTRICT DEV;
=Therapeutic or Preventive Procedure | - 290. *Constant
- (UMLS (HL7) C1547014) =Quantitative Concept =Kind of quantity;
|
- 241. (Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase
- [A modified form of asparaginase, an anticancer drug that belongs to the family of drugs derived from enzymes. ( NCI )] (UMLS (NCI) C0071568) =Amino Acid, Peptide, or Protein; Pharmacologic Substance; Enzyme =[AN000] ANTINEOPLASTICS;
ASPARAGINASE;
Glycol, polyethylene;
(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase =(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase;
PEGASPARGASE 750 UNT/ML;
| - 291. *Difference
- [A change in or difference between; usually represented by the 4th letter of the greek alphabet. ( NCI )] (UMLS (HL7) C1705241) Change;
Delta;
Difference =Quantitative Concept =Kind of quantity;
|
- 242. (o,p)-DDD
- [An anticancer drug used in treating adrenocortical cancer and ACTH-producing pituitary tumors (Cushing's disease). ( NCI )] (UMLS (NCI) C0026256) =Organic Chemical; Pharmacologic Substance ;
=[AN000] ANTINEOPLASTICS;
chlorohydrocarbon =MITOTANE 500 MG | - 292. *Dilution Factor (Titer)
- [Concentration of a solution as determined by titration. ( NCI )] (UMLS (HL7) C0475208) =Quantitative Concept =Kind of quantity;
|
- 243. (o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate
- [The tosylate salt form of bretylium, a quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia. ( NCI )] (UMLS (NCI) C0006168) =Organic Chemical; Pharmacologic Substance ;
=Bretylium Compounds;
bretylium =BRETYLIUM TOSYLATE 2 MG/ML;
BRETYLIUM TOSYLATE 4 MG/ML;
BRETYLIUM TOSYLATE 100 MG/ML;
BRETYLIUM TOSYLATE 50 MG/ML;
| - 293. *Entitic
- (UMLS (HL7) C1304535) =Quantitative Concept =Kind of quantity;
|
- 244. (OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum
- [A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death. Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04) ( NCI )] (UMLS (NCI) C0057856) =Organic Chemical; Pharmacologic Substance ;
| - 294. *Entitic Catalytic Activity
- (UMLS (HL7) C1264686) =Quantitative Concept =Kind of quantity;
|
- 245. (OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum
- [An orally administered third generation platinum compound with potential antineoplastic activity. Satraplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in cell growth inhibition and apoptosis. ( NCI )] (UMLS (NCI) C1142934) (OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum;
platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43);
Satraplatin;
=Organic Chemical; Pharmacologic Substance | - 295. *Entitic Number
- (UMLS (HL7) C1264689) =Quantitative Concept =Kind of quantity;
|
- 246. (p-Methoxyphenyl)trithiopropene
- [A drug that may reduce the risk of development or progression of cancer. ( NCI )] (UMLS (NCI) C0002937) =Organic Chemical; Pharmacologic Substance
| - 296. *Entitic Substance of Amount
- (UMLS (HL7) C1264685) =Quantitative Concept =Kind of quantity;
|
- 247. (R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium 4-Oxide
- [A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress. ( NCI )] (UMLS (NCI) C0216971) =Lipid; Pharmacologic Substance ;
=1,2-Dipalmitoylphosphatidylcholine;
COLFOSCERIL =CETYL ALCOHOL/COLFOSCERIL PALMITATE/TYLOXAPOL SUSP,ITRC | - 297. *Entitic Volume
- (UMLS (HL7) C1264690) =Quantitative Concept =Kind of quantity;
|
- 248. (R)-1-Methyl-4-(1-methylethenyl)cyclohexene
- [The dextro isomer of limonene, a natural cyclic monoterpene and major component of the oil extracted from citrus rind with chemo-preventive and antitumor activities. The metabolites of D-limonene, perillic acid, dihydroperillic acid, uroterpenol and limonene 1,2-diol are suggested to inhibit tumor growth through inhibition of p21-dependent signaling, induce apoptosis via the induction of the transforming growth factor beta-signaling pathway, inhibit post-translational modification of signal transduction proteins, result in G1 cell cycle arrest as well as cause differential expression of cell cycle- and apoptosis-related genes. ( NCI )] (UMLS (NCI) C0950252) 1-methyl-4-isopropenyl-1-cyclohexene;
D-Limonene;
LIMONENE, D-;
=Organic Chemical ;
| - 298. *Kinematic Viscosity
- (UMLS (HL7) C1547028) =Quantitative Concept =Kind of quantity;
|
- 249. (R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid
- [A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). ( NCI )] (UMLS (NCI) C1327754) R-Flurbiprofen;
=Organic Chemical; Pharmacologic Substance | - 299. *Length Increment
- (UMLS (HL7) C1547029) =Quantitative Concept =Kind of quantity;
|
- 250. (R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol
- [adenine nucleotide analog which inhibits adenine deaminase, used as an immunosuppressant to augment antineoplastics. ( CSP )] (UMLS (NCI) C0030896) =Nucleic Acid, Nucleoside, or Nucleotide; Antibiotic ;
=antineoplastic antibiotics;
[AN300] ANTINEOPLASTICS, ANTIMETABOLITES;
Coformycin;
deoxyribonucleoside;
[IM600] IMMUNE SUPPRESSANTS;
nucleoside analog =PENTOSTATIN 10 MG;
| - 300. *Liquefaction
- (UMLS (HL7) C1547030) =Quantitative Concept =Kind of quantity;
|
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