(+)-Camptothecin
[alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata; this compound selectively inhibits the nuclear enzyme DNA topoisomerase type I; several semisynthetic analogs of camptothecin have demonstrated antitumor activity. ( CSP )]
UMLS (NCI) C0006812- Organic Chemical
- Pharmacologic Substance
Relation/PAR: alkaloid
[AN000] ANTINEOPLASTICS
indolizine
[AN000] ANTINEOPLASTICS
indolizine
Relation/CHD: (s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione
(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione
(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione
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