(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate

[The citrate salt of an antineoplastic nonsteroidal selective estrogen receptor modulator (SERM). Tamoxifen competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA. The result is a reduction in DNA synthesis and cellular response to estrogen. In addition, tamoxifen up-regulates the production of transforming growth factor B (TGFb), a factor that inhibits tumor cell growth, and down-regulates insulin-like growth factor 1 (IGF-1), a factor that stimulates breast cancer cell growth. Tamoxifen also down-regulates protein kinase C (PKC) expression in a dose-dependant manner, thereby inhibiting signal transduction and producing an antiproliferative effect in tumors such as malignant glioma as well as in other cancers that express high levels of protein kinase C. ( NCI )]

UMLS (NCI) C0079589

Organic Chemical
Pharmacologic Substance

Relation/PAR: 1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene

Relation/CHD: TAMOXIFEN CITRATE 10 MG
TAMOXIFEN CITRATE 20 MG

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