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[1S-[1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid
[A synthetic lipid-lowering agent. Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04) ( NCI )]
UMLS (NCI) C0085542- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CV350] ANTILIPEMIC AGENTS
naphthalene
naphthalene
Relation/CHD: PRAVASTATIN SODIUM
PRAVASTATIN 40 MG
PRAVASTATIN 20 MG
PRAVASTATIN 80 MG
PRAVASTATIN 40 MG
PRAVASTATIN 20 MG
PRAVASTATIN 80 MG
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