T T T, T- T0 T1 T2 T3 T4 T9 TA TB TC TD TE TF TG TH TI TJ TK TL TM TN TO TP TQ TR TS TT TU TV TW TY TZ
1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate
[The hydrochloride salt form of tacrine, an aminoacridine derivative with cognitive stimulating property. Although the mechanism of action has not been fully elucidated, tacrine hydrochloride may bind reversibly to cholinesterase, acetylcholinesterase as well as butyrylcholinesterase, thereby decreasing the breakdown of acetylcholine, and prolonging synaptic actions as well as increased release of acetylcholine. In addition, this agent inhibits monoamine oxidase (MAO) and may inhibit the reuptake of catecholamines and serotonin. Finally, a novel mechanism of action studied in animal models suggests tacrine to attenuate the production of interleukin-1beta in the hippocampus and blood, thereby producing central and peripheral anti-inflammatory effects that may play a role in Alzheimer's disease. ( NCI )]
UMLS (NCI) C0771182Hydroaminacrine
TACRINE HYDROCHLORIDE
TACRINE HYDROCHLORIDE PREPARATION
TACRINE HYDROCHLORIDE
TACRINE HYDROCHLORIDE PREPARATION
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: tacrine
Relation/CHD: TACRINE HYDROCHLORIDE 20 MG
TACRINE HYDROCHLORIDE 40 MG
TACRINE HYDROCHLORIDE 10 MG
TACRINE HYDROCHLORIDE 30 MG
TACRINE HYDROCHLORIDE 40 MG
TACRINE HYDROCHLORIDE 10 MG
TACRINE HYDROCHLORIDE 30 MG
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