1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose, hydrochloride
[The hydrochloride salt of an antimetabolite analog of the nucleoside pyrimidine with antineoplastic activity. Gemcitabine is converted intracellularly to the active metabolites difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP). dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. ( NCI )]
UMLS (NCI) C07714882'Deoxy-2',2'-Difluorocytidine, Hydrochloride
Difluorodeoxycytidine Hydrochloride
Gemcitabine Hydrochloride
GEMCITABINE HYDROCHLORIDE PREPARATION
Difluorodeoxycytidine Hydrochloride
Gemcitabine Hydrochloride
GEMCITABINE HYDROCHLORIDE PREPARATION
- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
Relation/PAR: 1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose
Relation/CHD: GEMCITABINE HYDROCHLORIDE 1 GM
GEMCITABINE HYDROCHLORIDE 200 MG
GEMCITABINE HYDROCHLORIDE 200 MG
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