P P- P0 P1 P2 P3 P4 P5 P6 P7 P8 P9 PA PB PC PD PE PF PG PH PI PK PL PM PN PO PP PQ PR PS PT PU PV PW PX PY
1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride
[The hydrochloride salt form of propafenone with class 1C antiarrhythmic effects. Propafenone hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby reducing sodium influx required for the initiation and conduction of impulses in Purkinje and myocardial cells. This agent produces a marked depression of phase 0 and prolonged effective refractory period in the atrio-ventricular nodal and His-Purkinje tissue, resulting in a profound decrease in excitability, conduction velocity and automaticity, thereby counteracting atrial and ventricular arrythmias. ( NCI )]
UMLS (NCI) C0700465- Organic Chemical
- Pharmacologic Substance
Relation/PAR: PROPAFENONE
Relation/CHD: PROPAFENONE HYDROCHLORIDE 150 MG
PROPAFENONE HYDROCHLORIDE 225 MG
PROPAFENONE HYDROCHLORIDE 300 MG
PROPAFENONE HYDROCHLORIDE 225 MG
PROPAFENONE HYDROCHLORIDE 300 MG
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