2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-
[A synthetic nucleoside analog of cytosine with activity against human immunodeficiency virus type 1 reverse transcriptase. Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate. Incorporation of emtricabine 5'-triphosphate into nascent viral DNA results in chain termination. Emtricitabine 5'-triphosphate is a weak inhibitor of mammalian DNA polymerase alpha, beta, epsilon and mitochondrial DNA polymerase gamma. ( NCI )]
UMLS (NCI) C0909839EMTRICITABINE
EMTRICITABINE PREPARATION
FTC
EMTRICITABINE PREPARATION
FTC
- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
Relation/PAR: [AM800] ANTIVIRALS
Unclassified Ingredients
Unclassified Ingredients
Relation/CHD: EMTRICITABINE 200 MG
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