2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid
[A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity. As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins. This agent also may inhibit COX-2-mediated tumor angiogenesis. When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04) ( NCI )]
UMLS (NCI) C0012091- Organic Chemical
- Pharmacologic Substance
Relation/PAR: phenylacetate
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC
[MS102] NONSALICYLATE NSAIS, ANTIRHEUMATIC
[OP300] ANTI-INFLAMMATORIES, TOPICAL OPHTHALMIC
Relation/CHD: 2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt
2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt
2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt
2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt
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