2-Benzimidazolinebutryric acid, 1-methyl-5-bis(2-chloroethyl)amino-, hydrochloride
[The hydrochloride salt of bendamustine, a novel alkylating agent of the nitrogen mustard family with antitumor activity. Bendamustine, chemically related to the alkylator chlorambucil, has three active moieties: an alkylating group, in common with the nitrogen mustard family; a benzimidazole ring, which may act as a purine analog; and a butyric acid side-chain. This agent undergoes extensive first-pass metabolism by cytochrome p450 enzymes in vivo. One of the hydroxy metabolites, beta-hydroxybendamustine, alkylates and crosslinks macromolecules, thereby resulting in DNA, RNA and protein synthesis inhibition, and subsequently inducing apoptosis. ( NCI )]
UMLS (NCI) C0772139Bendamustin Hydrochloride
Bendamustine Hydrochloride
Bendamustine Hydrochloride
- Organic Chemical
- Pharmacologic Substance
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