[A sulfonamide derivative and a member of the quinazoline family, chemically related to thiazides, with diuretic, antihypertensive and antiurolithic properties. By blocking Na/Cl transporter, metolazone inhibits electrolyte reabsorption in the distal convoluted tubule and proximal tubule in the kidney. This prevents salt and fluid retention, leading to decreased plasma volume and reduce peripheral resistance of blood vessels, thereby reversal of hypertension. ( NCI )]
UMLS (NCI) C0025854 - Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CV701] THIAZIDES/RELATED DIURETICS
quinazoline
sulfonamide
Relation/CHD: METOLAZONE 0.5 MG
METOLAZONE 10 MG
METOLAZONE 2.5 MG
METOLAZONE 5 MG