21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
[The propionate salt form of halobetasol, a synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activities. Halobetasol, a topical steroid, diffuses across cell membranes to interact with cytoplasmic corticosteroid receptors located in both the dermal and intradermal cells, thereby activates gene expression of anti-inflammatory proteins mediated via corticosteroid receptor respond element. Specifically, this agent induces phospholipase A2 inhibitory proteins, which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes. As a result, halobetasol reduces edema, erythema and pruritus through its cutaneous effects on vascular dilation and permeability. ( NCI )]
UMLS (NCI) C0098735- Steroid
- Pharmacologic Substance
Relation/PAR: CLOBETASOL
Halobetasol
Halobetasol
Relation/CHD: Halobetasol
HALOBETASOL PROPIONATE 0.05 %
HALOBETASOL PROPIONATE 0.05 %
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