2C4
[A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04) ( NCI )]
UMLS (NCI) C13280252C4 Antibody
MoAb 2C4
Monoclonal Antibody 2C4
Pertuzumab
rhuMAb2C4
MoAb 2C4
Monoclonal Antibody 2C4
Pertuzumab
rhuMAb2C4
- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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