2PP2A

[Expressed by human SET Gene (NAP Family) in all tissues and responsive to serum factors, contact inhibition, or differentiation, 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A is a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI) ( NCI )]

UMLS (NCI) C1137947

HLA-DR Associated Protein II
I2PP2A
IGAAD
Inhibitor of GZMA-Activated DNase
PHAPII
Phosphatase 2A Inhibitor I2PP2A
SET
SET Protein
SET Translocation Inhibitor-2 of Protein Phosphatase-2A
TAF-IBeta
Template Activating Factor I Beta

Amino Acid, Peptide, or Protein
Biologically Active Substance

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