350/400 kDa PCAF-Associated Factor
[Encoded by human TRRAP Gene (TRA1 Kinase Family), 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats, are a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI) ( NCI )]
UMLS (NCI) C1336800PAF350/400
STAF40
TRA1 Homologue
Transformation/Transcription Domain-Associated Protein
TRRAP
STAF40
TRA1 Homologue
Transformation/Transcription Domain-Associated Protein
TRRAP
- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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