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4-(Aminomethyl)benzenesulfonamide Monoacetate
[The acetate salt form of mafenide, a synthetic sulfonamide analog of para-aminobenzoic acid (PABA) with topical anti-infective activity. Mafenide acetate competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, thereby interferes with normal folic acid metabolism. As a result de novo synthesis of pyrimidines, which requires folate metabolites, is impeded and subsequently DNA synthesis is affected. Mafenide acetate is bacteriostatic against many gram-negative and gram-positive organisms, including Pseudomonas aeruginosa and certain strains of anaerobes. ( NCI )]
UMLS (NCI) C0024453- Organic Chemical
- Pharmacologic Substance
Relation/PAR: MAFENIDE
[DE101] ANTIBACTERIAL, TOPICAL
[DE101] ANTIBACTERIAL, TOPICAL
Relation/CHD: MAFENIDE ACETATE 8.5 %
MAFENIDE ACETATE 50 GM
MAFENIDE ACETATE 50 GM
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