5-Fluorouracil/epi
[An injectable collagen matrix gel containing the antimetabolite fluorouracil and the symhathicomimetic agent epinephrine with potential antineoplastic activity. After intratumoral injection, fluorouracil is converted into the active metabolite 5-fluoroxyuridine monophosphate that competes with uracil during RNA synthesis whereas another active metabolite 5-5-fluoro-2'-deoxyuridine-5'-O-monophosphate inhibits thymidylate synthase, thereby interfering with DNA synthesis. Epinephrine, a potent vasoconstrictor, is added to the gel to enhance penetration of fluorouracil into the tumor tissue and reduce dispersion to the surrounding tissues thereby enhancing the local concentration of fluorouracil and increasing its anti-tumor activity. Intratumoral injection of fluorouracil combined with epinephrine may potentially increase chemotherapeutic efficacy compared to systemic administration and reduce systemic toxicity and side effects. ( NCI )]
UMLS (NCI) C0281426- Clinical Drug
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