UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
I I- I0 I1 I2 I3 I4 I5 I6 I7 I8 I9 IA IB IC ID IE IF IG IH II IK IL IM IN IO IP IQ IR IS IT IU IV IX
IOC IOD IOG IOH IOL IOM ION IOP IOS IOT IOV IOW IOX

5-Iodo-2-pyrimidinone-2'-deoxyribose

[An oral prodrug of 5-iododeoxyuridine (IUdR), an iodinated analogue of deoxyuridine and radiosensitizing agent. 5-Iodo-2-pyrimidinone-2-deoxyribose (IPdR) is efficiently converted to IUdR by a hepatic aldehyde oxidase. This results in increased IUdR plasma levels compared to oral IPdR and increased toxicity profile compared to intravenous administered IUdR. IUdR is incorporated into DNA during the S-phase of the cell cycle, thereby sensitizing cells to ionizing radiation by increasing DNA strand breaks. ( NCI )]
UMLS (NCI) C0088688
 
Nucleic Acid, Nucleoside, or Nucleotide
Pharmacologic Substance

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