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6 aminonicotinamide
[A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04) ( NCI )]
UMLS (CSP) C0000610- Organic Chemical
- Pharmacologic Substance
- Vitamin
- Hazardous or Poisonous Substance
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