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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
D D D- D0 D1 D2 D5 D7 D8 D9 DA DB DC DD DE DF DG DH DI DJ DK DL DM DN DO DP DR DS DT DU DV DW DX DY
DI DIA DIB DIC DID DIE DIF DIG DIH DII DIK DIL DIM DIN DIO DIP DIQ DIR DIS DIT DIU DIV DIZ

6-DIAZO-5-OXO-L-NORLEUCINE

[An antibiotic isolated from Streptomyces with potential antineoplastic activity. Diazooxonorleucine inhibits several glutamine-dependent biosynthetic pathways including the synthesis of D-glucosamine phosphate, purines and pyrimidines. As an L-glutamine antagonist, diazooxonorleucine inhibits phosphate-activated glutaminase, thereby interfering with glutamine metabolism, ultimately depleting cells of this essential amino acid and reducing the capacity to proliferate. Another mechanism of action including inhibition of glycoprotein, gamma-guanosine triphosphatease, DNA and RNA synthesis has been proposed. ( NCI )]
UMLS (NCI) C0012020
 
Amino Acid, Peptide, or Protein
Pharmacologic Substance

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