76 kD Tyrosine Phosphoprotein
[Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI) ( NCI )]
UMLS (NCI) C0296250- Amino Acid, Peptide, or Protein
- Biologically Active Substance
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