A A A+ A- A0 A1 A2 A3 A4 A5 A6 A7 A8 A9 AA AB AC AD AE AF AG AH AI AJ AK AL AM AN AO AP AQ AR AS AT AU AV AW AX AY AZ
8-Aminoisoindolo(1,2-b)quinazolin-12(10H)-one
[A water insoluble heterocyclic amide with potential antineoplastic activity. Batracylin appears to intercalate into DNA and interferes with topoisomerase II activity, thereby inhibiting DNA replication and repair, and RNA and protein synthesis. The acetylated form of batracylin is highly toxic and capable of inducing unscheduled DNA synthesis. This agent should, therefore, only be administered in patients with a slow acetylator NAT-2 genotype. ( NCI )]
UMLS (NCI) C0053006- Organic Chemical
- Pharmacologic Substance
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