90 kDa Ribosomal Protein S6 Kinase 5
[Widely expressed in heart, brain, placenta, lung, kidney, and liver by human RPS6KA5 Gene (S6 Ser/Thr Kinase Family), predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5 is a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI) ( NCI )]
UMLS (NCI) C0913240Mitogen- and Stress-Activated Protein Kinase 1
Nuclear Mitogen-and Stress-Activated Protein Kinase-1
Ribosomal Protein S6 Kinase 90kD Polypeptide 5
Ribosomal Protein S6 Kinase Alpha 5
RLSK
RPS6KA5
RSK-Like Protein Kinase
Nuclear Mitogen-and Stress-Activated Protein Kinase-1
Ribosomal Protein S6 Kinase 90kD Polypeptide 5
Ribosomal Protein S6 Kinase Alpha 5
RLSK
RPS6KA5
RSK-Like Protein Kinase
- Amino Acid, Peptide, or Protein
- Enzyme
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