[RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI) ( NCI )]
UMLS (NCI) C0285558 - Amino Acid, Peptide, or Protein
- Enzyme