APAF3

[Caspase-9 is encoded by the CASP9 Gene. Caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP. Caspase-9 and APAF1 bind to each other in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. Activation of procaspase-9 by APAF1 requires proteolytic cleavage to generate the mature caspase molecule. Activated caspase-9 in turn cleaves and activates caspase-3. APAF1-mediated processing of procaspase-9 occurs at asp315 by an intrinsic autocatalytic activity of procaspase-9 itself. APAF1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. Alternative splicing of this gene results in two transcript variants which encode different isoforms. (From LocusLink, OMIM and NCI) ( NCI )]

UMLS (NCI) C0910167

APAF-3
Apoptotic Protease Activating Factor 3
Apoptotic Protease MCH-6
CASP9
CASP-9
CASP9 Protein
Caspase 9, Apoptosis-Related Cysteine Protease
Caspase-9
EC 3.4.22.-
ICE-LAP6
ICE-Like Apoptotic Protease 6
MCH6

Amino Acid, Peptide, or Protein
Enzyme

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