UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BC BC- BCA BCC BCD BCE BCG BCH BCL BCN BCO BCP BCR BCS BCT BCX

B-Cell CLL Protein

[Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia. ( NCI )]
UMLS (NCI) C0672585
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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