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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
B B B0 B1 B4 B7 B8 BA BB BC BD BE BF BG BH BI BK BL BM BN BO BP BR BS BT BU BV BW BX BY BZ
BC BC- BCA BCC BCD BCE BCG BCH BCL BCN BCO BCP BCR BCS BCT BCX

B-Cell Lineage Specific Activator Protein

[Paired Box 5, encoded by the PAX5 gene, is a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink) ( NCI )]
UMLS (NCI) C0167636
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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