[May serve as part of a signaling pathway coupling the FC receptor to the activation of the respiratory burst. Furthermore, it may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils. p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK. Both are expressed predominantly in cells of the myeloid and b-lymphoid lineages, thus also called B-cell/Myeloid kinase. Contains 1 sh2 domain and 1 sh3 domain. Has been mapped to chromosomal location 20q11-q12. ( NCI )]
UMLS (NCI) C0919495Hemopoietic Cell Kinase p60
p60-HCK
- Amino Acid, Peptide, or Protein
- Enzyme