BLM
[BLM protein is a glycopeptide of 417 amino acids within which ATP binding domain is in amino acid 689-696, DEAH box in 795-798, and 2 putative nuclear localization signals in the C-term in 1334-1349. It is expressed at high level in S phase, and persists in G2/M and sharply declines in G1. It function as a 3'-5'DNA helicase, and probably plays a role in DNA replication and repair. It participates in a supercomplex of BRCA1 -associated proteins named BASC (BRCA1-Associated genome Surveillance Complex). ( NCI )]
UMLS (NCI) C0384701- Amino Acid, Peptide, or Protein
- Enzyme
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