Benazepril
[A dicarbocyl-containing peptide and angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. As a prodrug, benazepril is metabolized to its active form benazeprilat. Benazeprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II resulting in vasodilation. Benazeprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. ( NCI )]
UMLS (NCI) C0053091- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CV800] ACE INHIBITORS
benzazepine
benzazepine
Relation/CHD: Benazepril HCl
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