C-Jun Kinase 2
[Expressed as alpha-1, -2, beta-1, -2 isoforms by human MAPK9 Gene (MAPK Family), MAP Kinase 9 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI) ( NCI )]
UMLS (NCI) C1367019C-Jun N-Terminal Kinase 2
Jun Kinase
MAP Kinase 9
MAPK9
Stress-Activated Protein Kinase JNK2
Jun Kinase
MAP Kinase 9
MAPK9
Stress-Activated Protein Kinase JNK2
- Amino Acid, Peptide, or Protein
- Enzyme
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