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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
C C- C1 C3 C5 C6 C7 CA CB CC CD CE CF CG CH CI CJ CK CL CM CN CO CP CQ CR CS CT CU CV CW CX CY CZ
CC CC- CC4 CC5 CCA CCB CCC CCD CCE CCF CCG CCH CCI CCK CCL CCM CCN CCQ CCR CCS

CCAAT/Enhancer Binding Protein Alpha

[Human CCAAT/enhancer binding protein alpha (358 aa, 38 kD) is encoded by the human CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA) gene. This nuclear protein is a DNA-binding bZIP transcription factor that, as a homodimer, recognizes common motifs in both the promoter (CCAAT sequence) and enhancer (core homology sequence) regions of genes. CEBPA protein binds to the leptin gene promoter and modulates expression of the leptin protein, which is important in body weight homeostasis. CEBPA protein interacts with CDK2 and CDK4, thereby inhibiting kinase activity which results in cell growth arrest. This protein also plays an important role in the differentiation of immature granulocytes. Low levels of CEBPA protein has been associated with poor prognosis in acute myeloid leukemia patients. ( NCI )]
UMLS (NCI) C0378310
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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