CD CD1 CD2 CD3 CD4 CD5 CD6 CD7 CD8 CD9 CDA CDB CDC CDD CDE CDG CDH CDI CDK CDL CDM CDN CDO CDP CDR CDS CDT CDV CDW
CD127
[This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink) ( NCI )]
UMLS (NCI) C0083032- Amino Acid, Peptide, or Protein
- Immunologic Factor
- Receptor
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