CD CD1 CD2 CD3 CD4 CD5 CD6 CD7 CD8 CD9 CDA CDB CDC CDD CDE CDG CDH CDI CDK CDL CDM CDN CDO CDP CDR CDS CDT CDV CDW
CD31 Antigen
[A cell adhesion molecule present on virtually all monocytes, platelets, and granulocytes, CD31 is highly expressed on endothelial cells and concentrated at the junctions between them. An integral membrane glycoprotein that contains six extracellular Ig-like domains, one transmembrane domain, and a cytoplasmic domain, CD31 is most similar to the CAM subgroup of the Ig superfamily. PECAM1 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation. Ig superfamily members mediate cell adhesion, or antigen recognition, T-cell receptors, and MHC molecules. A subgroup contains one or more cytoplasmic ITIM motifs. PECAM1 has six ITIMs and may serve as a negative regulator of platelet-collagen interactions that may limit growth of platelet thrombi on collagen surfaces. (from OMIM 173445 and NCI) ( NCI )]
UMLS (NCI) C0081939- Amino Acid, Peptide, or Protein
- Immunologic Factor
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