CNOS
[Expressed in platelets and endothelia by human NOS3 Gene (NOS Family), conserved constitutive 1202-aa 133-kDa Nitric Oxide Synthase 3 is a calcium/calmodulin stimulated homodimer stabilized by BH4 that contains a flavodoxin-like domain, binds FAD and FMN cofactors, and synthesizes NO from L-arginine. Endothelial NO appears to exert EDRF activity that inhibits vascular smooth muscle contraction through a cGMP pathway. NOS3 activity also inhibits platelet aggregation and mediates VEGF-induced angiogenesis. Vascular shear stress activates endothelial PI3K and AKT, which directly phosphorylates (Ser1177) and enhances NOS3 activity and calcium sensitivity. Potentially influencing the control of energy balance, NO also triggers cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI) ( NCI )]
UMLS (NCI) C0669365- Amino Acid, Peptide, or Protein
- Enzyme
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