[Interleukin-17, encoded by the IL17 gene, is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (From LocusLink) ( NCI )]
UMLS (NCI) C0384648 - Amino Acid, Peptide, or Protein
- Immunologic Factor