CUL2

1. [This gene is involved in protein degradation and the negative regulation of cell proliferation. ( NCI )]
   UMLS (NCI) C1332810
   
   CUL2 Gene
   Cullin 2 Gene
    

   Gene or Genome

2. [Encoded by human CUL2 Gene (Cullin Family), 745-aa 87-kDa Cullin 2 is a component of multisubunit E3 ubiquitin ligase complexes with elongin BC complexes and other factors. Involved in the third step of ubiquitin conjugation, CUL2 may act as scaffold that positions substrate and the ubiquitin-conjugating enzyme. CUL2 interacts with RBX1, RNF7, and TIP120A/CAND1. (NCI) ( NCI )]
   UMLS (NCI) C1333165
   
   Cullin 2
   Cullin 2 Protein
   Cullin Homolog 2
    

   Amino Acid, Peptide, or Protein

   Biologically Active Substance