Ch-1PTPase

[Alternative alpha, beta, gamma, and delta isoforms of Protein Tyrosine Phosphatase PCPTP1 are expressed in brain, kidney, placenta, small intestine, stomach, uterus, or prostate by human PTPRR Gene (PTP Family). Type I membrane protein receptor-type PTP isoforms alpha and beta possess an extracellular region, a single transmembrane region, and a single intracellular catalytic domain. Cytoplasmic nonreceptor-type PTP isoforms gamma and delta contain 1 PTP domain and locate in the perinuclear area. PTPRR sequesters inactive MAPKs, such as MAPK1, MAPK3, and MAPK14, in the cytoplasm. MAPKs likely bind to a dephosphorylated kinase interacting motif, phosphorylation of which by Protein Kinase A complex releases MAPKs for activation and nuclear translocation. Mouse Ptprr is expressed predominately in the brain and regulates MAP kinase activity and localization. (NCI) ( NCI )]

UMLS (NCI) C0963314

EC-PTP
NC-PTPCOM1
PCPTP1
Protein Tyrosine Phosphatase Cr1PTPase
Protein Tyrosine Phosphatase NC-PTPCOM1
Protein Tyrosine Phosphatase Receptor Type R
Protein Tyrosine Phosphatase-PCPTP1
PTPBR7
PTPRR
PTP-SL
Receptor Type Protein Tyrosine Phosphatase R

Amino Acid, Peptide, or Protein
Enzyme
Receptor

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