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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
C C- C1 C3 C5 C6 C7 CA CB CC CD CE CF CG CH CI CJ CK CL CM CN CO CP CQ CR CS CT CU CV CW CX CY CZ
CH CH1 CHA CHC CHD CHE CHG CHH CHI CHK CHL CHN CHO CHP CHR CHS CHU CHV CHY

Chemokine (C-X-C Motif) Ligand 12

[Encoded by human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family), alternative alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1 are chemoattractant ligands for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional C-terminal sequence. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI) ( NCI )]
UMLS (NCI) C0218504
 
Amino Acid, Peptide, or Protein
Immunologic Factor

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