CpG ODN
[A synthetic oligodeoxynucleotide containing multiple repeats of unmethylated CpG motifs (CpG ODN) with immunostimulatory activity. Upon entering the cell via endocytosis, CpG-28 activates numerous signaling transduction pathways resulting in the release of multiple cytokines. CpG-28 has immunomodulatory properties with direct activation of B-lymphocytes, dendritic and NK cells resulting in the stimulation of innate immunity and antibody-dependant cell cytotoxicity (ADCC). Additionally, this agent indirectly modulates T-cell responses though the release of cytokines (IL-12 and IFN gamma) to induce a preferential shift to the Th1 (helper) phenotype resulting in enhanced CD8+ cellular cytotoxicity. ( NCI )]
UMLS (NCI) C0914671CpG oligodeoxynucleotide
CpG-28
CpG-28 Oligodeoxynucleotide
CpG-28
CpG-28 Oligodeoxynucleotide
- Nucleic Acid, Nucleoside, or Nucleotide
- Pharmacologic Substance
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