Fluoxamine
[A 2-aminoethyl oxime ether of aralkylketones, with antidepressant, antiobsessive-compulsive, and anxiolytic properties. Fluvoxamine, chemically unrelated to other selective serotonin reuptake inhibitors, selectively blocks serotonin reuptake by inhibiting the serotonin reuptake pump at the presynaptic neuronal membrane. This increases serotonin levels within the synaptic cleft, prolongs serotonergic transmission and decreased serotonin turnover, thereby leading to antidepressant, anxiolytic and antiobsessive-compulsive effects. Fluvoxamine shows no significant affinity for histaminergic, alpha or beta adrenergic, muscarinic, or dopaminergic receptors in vitro. ( NCI )]
UMLS (NCI) C0085228- Organic Chemical
- Pharmacologic Substance
Relation/PAR: [CN600] ANTIDEPRESSANTS
oxime
serotonin inhibitor
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS
[CN609] ANTIDEPRESSANTS, OTHER
oxime
serotonin inhibitor
[CN302] BENZODIAZEPINE DERIVATIVE, SEDATIVES/HYPNOTICS
[CN609] ANTIDEPRESSANTS, OTHER
Relation/CHD: FLUVOXAMINE MALEATE
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