GM-CSF plasmid DNA sarcoma vaccine
[An autologous sarcoma cell vaccine with potential immunostimulatory activity. Tumor cells harvested from a patient with sarcoma are transfected with a plasmid DNA encoding for human sargramostim (GM-CSF) using a particle-mediated gene transfer (PMGT) technique, which avoids the use infectious components. Vaccination with an autologous sargramostim sarcoma vaccine produces high levels of GM-CSF, a cytokine that enhances antigen presentation by activated macrophages and increases the recognition of weakly immunogenic tumors by cytotoxic T-lymphocytes. ( NCI )]
UMLS (NCI) C0393070- Amino Acid, Peptide, or Protein
- Pharmacologic Substance
- Immunologic Factor
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