GR 85548A
[The hydrochloride salt form of naratriptan, a sulfonamide with selective serotonin (5-HT) 1 receptor agonistic activity and anti-migraine property. Naratriptan hydrochloride binds selectively and with high affinity to the 5-HT1D and 5-HT1B receptor subtypes. Activation of these 5-HT1D/B receptors located on intracranial blood vessels leads to vasoconstriction and provides relief of migraine headaches. Naratriptan hydrochloride may also exerts its effect by stimulation of 5-HT1D/1B receptors on sensory nerve endings in the trigeminal system thereby decreasing the release of pro-inflammatory neuropeptides. ( NCI )]
UMLS (NCI) C0771993Naratriptan Hydrochloride
NARATRIPTAN HYDROCHLORIDE PREPARATION
N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride
NARATRIPTAN HYDROCHLORIDE PREPARATION
N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride
- Organic Chemical
- Pharmacologic Substance
Relation/PAR: NARATRIPTAN
Relation/CHD: NARATRIPTAN HYDROCHLORIDE 1 MG
NARATRIPTAN HYDROCHLORIDE 2.5 MG
NARATRIPTAN HYDROCHLORIDE 2.5 MG
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