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UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM
%
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
G G0 G1 G2 G3 G4 GA GB GC GD GE GF GG GH GI GL GM GN GO GP GQ GR GS GT GU GV GW GX GY GZ G%
GR GR GR6 GRA GRB GRC GRE GRF GRI GRK GRN GRO

GRB10

[Grb10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. It interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated. Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28) ( NCI )]
UMLS (NCI) C0296936
 
Amino Acid, Peptide, or Protein
Biologically Active Substance

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