General Transcription Factor Gene
[Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (PolII) and a cadre of transcription factors. These factors can be divided into 2 classes on the basis of their function: the general factors that are required for transcription of all PolII genes, and sequence-specific factors that are required for regulating expression. The general transcription factors and PolII form a specific multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically located 25-30 bp upstream of the transcriptional start site or initiator element. Sequence-specific transcription factors that bind to DNA-sequence elements located proximal and distal to the core promoter elements can dramatically enhance or repress transcription. (from OMIM 189962) ( NCI )]
UMLS (NCI) C0812327Proto-Oncogene, Transcription Factor
Transcription Factor Gene
Transcription Factor Gene
- Gene or Genome
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