H-2RIIBP
[Expressed as 2 alternative isoforms by human RXRB Gene (NR2/RXR Family), nuclear Retinoid X Receptor Beta is a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRB forms homodimers and heterodimers with RA-, TH-, and vitamin D receptors and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI) ( NCI )]
UMLS (NCI) C0527031- Amino Acid, Peptide, or Protein
- Receptor
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